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Role of microRNAs in effector versus regulatory CD4+ T cell differentiation during (auto)immune responses in vivo

2024-05Póster em conferência Acesso aberto
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datacite.subject.sdg03:Saúde de Qualidade
dc.contributor.authorCunha, Carolina
dc.contributor.authorRomero, Paula Vargas
dc.contributor.authorInácio, Daniel
dc.contributor.authorSobral, Daniel
dc.contributor.authorCosta, Marina
dc.contributor.authorPapotto, Pedro
dc.contributor.authorEnguita, Francisco
dc.contributor.authorGomes, Anita
dc.contributor.authorSilva-Santos, Bruno
dc.date.accessioned2026-09-21T08:55:47Z
dc.date.available2026-09-21T08:55:47Z
dc.date.issued2024-05
dc.description.abstractIntroduction: MicroRNAs are an abundant class of evolutionarily conserved small non-coding RNA species that control gene expression at the post-transcriptional level and are estimated to regulate most developmental and physiological processes. They are involved in many aspects of immunity, notably in the differentiation and function of CD4+ T cell subsets. CD4+ T cells play critical roles in the host defense against pathogens, but they are also responsible for the generation of immune-mediated diseases. This arises from an incorrect balance between the various CD4+ T cell subsets, namely pro-inflammatory effector T cells, including the IFN-g-producers T helper 1 (Th1) cells and the IL-17-producers Th17 cells, and anti-inflammatory regulatory T cells (FoxP3+ subset). Although various individual miRNAs have been implicated in CD4+ T cell biology, data are missing on how miRNA regulatory networks may control the balance between effector and regulatory T cells in pathophysiological conditions in vivo. Aim of the study: To dissect the role of miRNAs in the post-transcriptional regulation of effector and regulatory CD4+ T cell differentiation in vivo.eng
dc.identifier.citationCunha C, Romero PV, Inácio D, Sobral D, Costa M, Gomes AQ, et al. Role of microRNAs in effector versus regulatory CD4+ T cell differentiation during (auto)immune responses in vivo. In: Regulatory & Non-Coding RNAs [virtual meeting], May 14-18, 2024.
dc.identifier.urihttp://hdl.handle.net/10400.21/23095
dc.language.isoeng
dc.peerreviewedyes
dc.relation.hasversionhttps://meetings.cshl.edu/archivesmeetings.aspx?meet=REGRNA&year=24
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectmicroRNAs
dc.subjectRegulatory CD4+ T cell
dc.subjectIn vivo
dc.titleRole of microRNAs in effector versus regulatory CD4+ T cell differentiation during (auto)immune responses in vivoeng
dc.typeconference poster
dspace.entity.typePublication
oaire.citation.conferenceDate2024-05
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameGomes
person.givenNameAnita
person.identifier.ciencia-id4B10-E015-52B7
person.identifier.orcid0000-0002-3348-0448
person.identifier.ridC-3580-2014
person.identifier.scopus-author-id7202386033
relation.isAuthorOfPublication2b5a3f0a-29c2-4ecd-a83f-50d0b99a4875
relation.isAuthorOfPublication.latestForDiscovery2b5a3f0a-29c2-4ecd-a83f-50d0b99a4875

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