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Role of microRNAs in effector versus regulatory CD4+ T cell differentiation during (auto)immune responses in vivo
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| Abstract | 34.7 KB | Adobe PDF |
Orientador(es)
Resumo(s)
Introduction: MicroRNAs are an abundant class of evolutionarily conserved small non-coding RNA species that control gene expression at the post-transcriptional level and are estimated to regulate most developmental and physiological processes. They are involved in many aspects of immunity, notably in the differentiation and function of CD4+ T cell subsets. CD4+ T cells play critical roles in the host defense against pathogens, but they are also responsible for the generation of immune-mediated diseases. This arises from an incorrect balance between the various CD4+ T cell subsets, namely pro-inflammatory effector T cells, including the IFN-g-producers T helper 1 (Th1) cells and the IL-17-producers Th17 cells, and anti-inflammatory regulatory T cells (FoxP3+ subset). Although various individual miRNAs have been implicated in CD4+ T cell biology, data are missing on how miRNA regulatory networks may control the balance between effector and regulatory T cells in pathophysiological conditions in vivo. Aim of the study: To dissect the role of miRNAs in the post-transcriptional regulation of effector and regulatory CD4+ T cell differentiation in vivo.
Descrição
Palavras-chave
microRNAs Regulatory CD4+ T cell In vivo
Contexto Educativo
Citação
Cunha C, Romero PV, Inácio D, Sobral D, Costa M, Gomes AQ, et al. Role of microRNAs in effector versus regulatory CD4+ T cell differentiation during (auto)immune responses in vivo. In: Regulatory & Non-Coding RNAs [virtual meeting], May 14-18, 2024.