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The apicomplexan parasite Toxoplasma gondii

2022-01Journal article Open access
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dc.contributor.authorDelgado, Inês L. S.
dc.contributor.authorZúquete, Sara
dc.contributor.authorSantos, Dulce
dc.contributor.authorBasto, Afonso P.
dc.contributor.authorLeitão, Alexandre
dc.contributor.authorNolasco, Sofia
dc.date.accessioned2022-01-27T11:26:29Z
dc.date.available2022-01-27T11:26:29Z
dc.date.issued2022-01
dc.descriptionPTDC/CVT-CVT/31840/2017pt_PT
dc.descriptionEXPL/CVT-EPI/1945/2013pt_PT
dc.description.abstractToxoplasma gondii is a ubiquitous zoonotic parasite with an obligatory intracellular lifestyle. It relies on a specialized set of cytoskeletal and secretory organelles for host cell invasion. When infecting its felid definitive host, T. gondii undergoes sexual reproduction in the intestinal epithelium, producing oocysts that are excreted with the feces and sporulate in the environment. In other hosts and/or tissues, T. gondii multiplies by asexual reproduction. Rapidly dividing tachyzoites expand through multiple tissues, particularly nervous and muscular tissues, and eventually convert to slowly dividing bradyzoites which produce tissue cysts, structures that evade the immune system and remain infective within the host. Infection normally occurs through ingestion of sporulated oocysts or tissue cysts. While T. gondii is able to infect virtually all warm-blooded animals, most infections in humans are asymptomatic, with clinical disease occurring most often in immunocompromised hosts or fetuses carried by seronegative mothers that are infected during pregnancy.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationDelgado IL, Zúquete S, Santos D, Basto AP, Leitão A, Nolasco S. The apicomplexan parasite Toxoplasma gondii. Encyclopedia. 2022;2(1):189-211.pt_PT
dc.identifier.doi10.3390/encyclopedia2010012pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/14211
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationProgramming the type and localization of adaptive immunity by targeting TLR2: a strategy for the development of novel veterinary vaccines
dc.relation.publisherversionhttps://www.mdpi.com/2673-8392/2/1/12pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectToxoplasma gondiipt_PT
dc.subjectToxoplasmosispt_PT
dc.subjectParasitept_PT
dc.subjectTissue cystpt_PT
dc.subjectEndodyogenypt_PT
dc.subjectLytic cyclept_PT
dc.subjectLife cyclept_PT
dc.subjectOocystpt_PT
dc.subjectApicomplexapt_PT
dc.subjectEXPL/CVT-EPI/1945/2013pt_PT
dc.subjectPTDC/CVT-CVT/31840/2017pt_PT
dc.titleThe apicomplexan parasite Toxoplasma gondiipt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleProgramming the type and localization of adaptive immunity by targeting TLR2: a strategy for the development of novel veterinary vaccines
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FCVT-CVT%2F31840%2F2017/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/EXPL%2FCVT-EPI%2F1945%2F2013/PT
oaire.citation.endPage211pt_PT
oaire.citation.issue1pt_PT
oaire.citation.startPage189pt_PT
oaire.citation.titleEncyclopediapt_PT
oaire.citation.volume2pt_PT
oaire.fundingStream3599-PPCDT
oaire.fundingStream3599-PPCDT
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isProjectOfPublicationb2de9eb1-e0ee-4ef8-a23b-0db5d3d1b943
relation.isProjectOfPublication99775d97-1a92-4d30-b424-1ccabf7ecfb0
relation.isProjectOfPublication.latestForDiscovery99775d97-1a92-4d30-b424-1ccabf7ecfb0

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