Repository logo
 
Publication

The efficacy and safety of antifungal agents for managing oral candidiasis in oncologic patients: a systematic review with network meta-analysis

2024-09Journal article Open access
Simple item page
dc.contributor.authorLima, Amanda F.
dc.contributor.authorFagundes, Vitor L.
dc.contributor.authorMarques, Nathália B.
dc.contributor.authorBorba, Helena L.
dc.contributor.authorDomingos, Eric L.
dc.contributor.authorTonin, Fernanda
dc.contributor.authorPontarolo, Roberto.
dc.date.accessioned2024-11-13T16:01:36Z
dc.date.available2024-11-13T16:01:36Z
dc.date.issued2024-09
dc.description.abstractThis study aimed at synthesizing the available evidence on the comparative safety and efficacy of antifungal agents for preventing or treating oral candidiasis (OC) in oncologic patients. A systematic review following international recommendations was performed (PROSPERO CRD42024507745). A comprehensive search was conducted in PubMed, Scopus, and Web of Science (Feb 2024) to retrieve randomized controlled trials evaluating the clinical effects of antifungal agents in the management of OC in this vulnerable population. Network meta-analyses were performed to evaluate the most prevalent outcomes, with findings reported as odds ratios (ORs) with 95% confidence intervals (CIs). Overall, 24 trials were included, of which 10 addressed OC treatment and 14 disease prophylaxis (n=3449 patients). Fluconazole had the most significant rates of clinical cure when compared to placebo (OR 0.09 [95% CI 0.01-0.69]), amphotericin B (0.21 [95% CI 0.07-0.65]) and itraconazole (OR 0.58 [95% CI 0.34-0.99]); ketoconazole was also superior to placebo for this outcome (OR 0.10 [95% CI 0.03, 0.36]). All antifungal agents presented significantly higher rates of prophylaxis success compared to the absence of an active agent. While these therapies were generally considered safe, only four studies provided data on adverse events, primarily related to gastrointestinal issues. In oncologic patients, azoles (fluconazole, ketoconazole) should be used as a first-line approach for OC treatment. The selection of antifungal agents for disease prophylaxis should consider, among others, patients' clinical characteristics and preferences. Economic and quality of life-related outcomes should be further addressed in future studies.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationLima AF, Fagundes VL, Marques NB, Borba HL, Domingos EL, Tonin FS, et al. The efficacy and safety of antifungal agents for managing oral candidiasis in oncologic patients: a systematic review with network meta-analysis. Cureus. 2024;16(9):e69340.pt_PT
dc.identifier.doi10.7759/cureus.69340pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/17898
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringer Naturept_PT
dc.relation.publisherversionhttps://www.cureus.com/articles/291842-the-efficacy-and-safety-of-antifungal-agents-for-managing-oral-candidiasis-in-oncologic-patients-a-systematic-review-with-network-meta-analysis#!/pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectAntifungal agentspt_PT
dc.subjectOncologic carept_PT
dc.subjectOral candidiasispt_PT
dc.subjectTreatment choicespt_PT
dc.subjectNetwork meta-analysispt_PT
dc.titleThe efficacy and safety of antifungal agents for managing oral candidiasis in oncologic patients: a systematic review with network meta-analysispt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue9pt_PT
oaire.citation.startPagee69340pt_PT
oaire.citation.titleCureuspt_PT
oaire.citation.volume16pt_PT
person.familyNameTonin
person.givenNameFernanda
person.identifier.ciencia-idD01C-C700-9411
person.identifier.orcid0000-0003-4262-8608
person.identifier.ridO-2050-2017
person.identifier.scopus-author-id56085115800
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication61ded30e-ecec-4b3e-b953-2293e080ebdd
relation.isAuthorOfPublication.latestForDiscovery61ded30e-ecec-4b3e-b953-2293e080ebdd

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
The efficacy and safety of antifungal agents for managing oral candidiasis in oncologic patients_a systematic review with network meta-analysis.pdf
Size:
3.19 MB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

ESTeSL - Artigos