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Integrated community-based intervention for urinary schistosomiasis and soil-transmitted helminthiasis in children from Caxito, Angola

2020-02Journal article Open access
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dc.contributor.authorLemos, Manuel
dc.contributor.authorFançony, Cláudia
dc.contributor.authorMoura, Sofia
dc.contributor.authorMirante, Clara
dc.contributor.authorSousa, Pinto de
dc.contributor.authorBarros, Henrique
dc.contributor.authorNery, Susana
dc.contributor.authorBrito, Miguel
dc.date.accessioned2020-02-19T12:48:00Z
dc.date.available2020-02-19T12:48:00Z
dc.date.issued2020-02
dc.description.abstractBackground: Schistosomiasis and soil-transmitted helminths (STH) infections are major public health problems. We aimed to study the 6-mo impact of mass drug administration with praziquantel and albendazole on urinary schistosomiasis and STH. Methods: We examined children (aged 2–15 y) from one hamlet, who provided urine and feces samples at baseline (n=197), 1 mo (n=102), and 6 mo (n=92); 67 completed the protocol. Results: At baseline, 47/67 (70.1%) children presented Schistosoma haematobium (75.8% in the baseline total sample) and 12/67 (17.9%) with STH (30.5% in the initial sample, p=0.010). Among the children, 47.3% had heavy Schistosoma haematobium infection. The most frequent STH was Trichuris trichiura in 9.0%. We also found Hymenolepis nana (13.2%) and Plasmodium falciparum (9.1%) infections and anemia (82.1%). One mo after chemotherapy there was a significant (p=0.013) reduction of Schistosoma haematobium prevalence (23.5%) and a high egg reduction rate (86.9%). Considering the sample of 67 children, the mean egg concentration was 498 at baseline, 65 at 1 mo, and 252 at 6 mo (p<0.05). We also observed a reduction in STH infections, 50% in Ascaris lumbricoides, 33.3% in T. trichiura, and 50% in hookworms. At 6 mo, the prevalence of Schistosoma haematobium (76.1%) was similar to the baseline and the STH reduction was not significant. Conclusions: Longitudinal studies have reported many losses in these settings, but we were able to show that mass drug administration for control of schistosomiasis and STH presents low effectiveness, that reinfections occur rapidly and that stand-alone anthelmintic therapy is not a sustainable choice.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationLemos M, Fançony C, Moura S, Mirante C, Barros H, Brito M, et al. Integrated community-based intervention for urinary schistosomiasis and soil-transmitted helminthiasis in children from Caxito, Angola. Int Health. 2020;12(2):86-94.pt_PT
dc.identifier.doi10.1093/inthealth/ihz055pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/11119
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherOxford University Presspt_PT
dc.relation.publisherversionhttps://academic.oup.com/inthealth/article/12/2/86/5530565pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectChemotherapypt_PT
dc.subjectMass drug administrationpt_PT
dc.subjectSchistosomiasis haematobiapt_PT
dc.subjectSoil-transmitted helminthspt_PT
dc.subjectChildrenpt_PT
dc.subjectAngolapt_PT
dc.subjectCaxitopt_PT
dc.titleIntegrated community-based intervention for urinary schistosomiasis and soil-transmitted helminthiasis in children from Caxito, Angolapt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage94pt_PT
oaire.citation.issue2pt_PT
oaire.citation.startPage86pt_PT
oaire.citation.titleInternational Healthpt_PT
oaire.citation.volume12pt_PT
person.familyNameBrito
person.givenNameMiguel
person.identifier.ciencia-id231F-F341-7E93
person.identifier.orcid0000-0001-6394-658X
person.identifier.ridA-7970-2016
person.identifier.scopus-author-id35224551000
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication4252d8e0-800c-4d67-8b13-0b711d860669
relation.isAuthorOfPublication.latestForDiscovery4252d8e0-800c-4d67-8b13-0b711d860669

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