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Harmonized human biomonitoring in European children, teenagers and adults: EU-wide exposure data of 11 chemical substance groups from the HBM4EU Aligned Studies (2014–2021)

2023-02Journal article Open access
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dc.contributor.authorGovarts, Eva
dc.contributor.authorGilles, Liese
dc.contributor.authorRodriguez Martin, Laura
dc.contributor.authorSantonen, Tiina
dc.contributor.authorApel, Petra
dc.contributor.authorAlvito, Paula
dc.contributor.authorAnastasi, Elena
dc.contributor.authorAndersen, Helle Raun
dc.contributor.authorAndersson, Anna-Maria
dc.contributor.authorAndryskova, Lenka
dc.contributor.authorAntignac, Jean-Philippe
dc.contributor.authorAppenzeller, Brice
dc.contributor.authorBarbone, Fabio
dc.contributor.authorBarnett-Itzhaki, Zohar
dc.contributor.authorBarouki, Robert
dc.contributor.authorBerman, Tamar
dc.contributor.authorBil, Wieneke
dc.contributor.authorBorges, Teresa
dc.contributor.authorBuekers, Jurgen
dc.contributor.authorCañas-Portilla, Ana
dc.contributor.authorCovaci, Adrian
dc.contributor.authorCsako, Zsofia
dc.contributor.authorDen Hond, Elly
dc.contributor.authorDvorakova, Darina
dc.contributor.authorFabelova, Lucia
dc.contributor.authorFletcher, Tony
dc.contributor.authorFrederiksen, Hanne
dc.contributor.authorGabriel, Catherine
dc.contributor.authorGanzleben, Catherine
dc.contributor.authorGöen, Thomas
dc.contributor.authorHalldorsson, Thorhallur I.
dc.contributor.authorHaug, Line S.
dc.contributor.authorHorvat, Milena
dc.contributor.authorHuuskonen, Pasi
dc.contributor.authorImboden, Medea
dc.contributor.authorJagodic Hudobivnik, Marta
dc.contributor.authorJanasik, Beata
dc.contributor.authorJanev Holcer, Natasa
dc.contributor.authorKarakitsios, Spyros
dc.contributor.authorKatsonouri, Andromachi
dc.contributor.authorKlanova, Jana
dc.contributor.authorKokaraki, Venetia
dc.contributor.authorKold Jensen, Tina
dc.contributor.authorKoponen, Jani
dc.contributor.authorLaeremans, Michelle
dc.contributor.authorLaguzzi, Federica
dc.contributor.authorLange, Rosa
dc.contributor.authorLemke, Nora
dc.contributor.authorLignell, Sanna
dc.contributor.authorLindroos, Anna Karin
dc.contributor.authorVicente, Joana Lobo
dc.contributor.authorLuijten, Mirjam
dc.contributor.authorMakris, Konstantinos C.
dc.contributor.authorMazej, Darja
dc.contributor.authorMelymuk, Lisa
dc.contributor.authorMeslin, Matthieu
dc.contributor.authorMol, Hans
dc.contributor.authorMontazeri, Parisa
dc.contributor.authorMurawski, Aline
dc.contributor.authorNamorado, Sónia
dc.contributor.authorNiemann, Lars
dc.contributor.authorNübler, Stefanie
dc.contributor.authorNunes, Baltazar
dc.contributor.authorOlafsdottir, Kristin
dc.contributor.authorMurinova, Lubica Palkovicova
dc.contributor.authorPapaioannou, Nafsika
dc.contributor.authorPedraza-Diaz, Susana
dc.contributor.authorPiler, Pavel
dc.contributor.authorPlichta, Veronika
dc.contributor.authorPoteser, Michael
dc.contributor.authorProbst-Hensch, Nicole
dc.contributor.authorRambaud, Loïc
dc.contributor.authorRauscher-Gabernig, Elke
dc.contributor.authorRausova, Katarina
dc.contributor.authorRemy, Sylvie
dc.contributor.authorRiou, Margaux
dc.contributor.authorRosolen, Valentina
dc.contributor.authorRousselle, Christophe
dc.contributor.authorRüther, Maria
dc.contributor.authorSarigiannis, Denis
dc.contributor.authorSilva, Maria J.
dc.contributor.authorŠlejkovec, Zdenka
dc.contributor.authorTratnik, Janja Snoj
dc.contributor.authorStajnko, Anja
dc.contributor.authorSzigeti, Tamas
dc.contributor.authorTarazona, José V.
dc.contributor.authorThomsen, Cathrine
dc.contributor.authorTkalec, Žiga
dc.contributor.authorTolonen, Hanna
dc.contributor.authorTrnovec, Tomas
dc.contributor.authorUhl, Maria
dc.contributor.authorVan Nieuwenhuyse, An
dc.contributor.authorVasco, Elsa
dc.contributor.authorVerheyen, Veerle J.
dc.contributor.authorViegas, Susana
dc.contributor.authorVinggaard, Anne Marie
dc.contributor.authorVogel, Nina
dc.contributor.authorVorkamp, Katrin
dc.contributor.authorWasowicz, Wojciech
dc.contributor.authorWeber, Till
dc.contributor.authorWimmerova, Sona
dc.contributor.authorWoutersen, Marjolijn
dc.contributor.authorZimmermann, Philipp
dc.contributor.authorZvonar, Martin
dc.contributor.authorKoch, Holger
dc.contributor.authorKolossa-Gehring, Marike
dc.contributor.authorEsteban López, Marta
dc.contributor.authorCastaño, Argelia
dc.contributor.authorStewart, Lorraine
dc.contributor.authorSepai, Ovnair
dc.contributor.authorSchoeters, Greet
dc.date.accessioned2023-02-14T11:48:37Z
dc.date.available2023-02-14T11:48:37Z
dc.date.issued2023-02
dc.descriptionHBM4EU is co-financed under Horizon 2020 (grant agreement No 733032).pt_PT
dc.description.abstractAs one of the core elements of the European Human Biomonitoring Initiative (HBM4EU) a human biomonitoring (HBM) survey was conducted in 23 countries to generate EU-wide comparable HBM data. This survey has built on existing HBM capacity in Europe by aligning national or regional HBM studies, referred to as the HBM4EU Aligned Studies. The HBM4EU Aligned Studies included a total of 10,795 participants from three age groups: (i) 3,576 children aged 6-12 years, (ii) 3,117 teenagers aged 12-18 years, and (iii) 4,102 young adults aged 20-39 years. The participants were recruited between 2014 and 2021 in 11-12 countries per age group, geographically distributed across Europe. Depending on the age group, internal exposure to phthalates and the substitute DINCH, halogenated and organophosphorus flame retardants, per- and polyfluoroalkyl substances (PFASs), cadmium, bisphenols, polycyclic aromatic hydrocarbons (PAHs), arsenic species, acrylamide, mycotoxins (deoxynivalenol (total DON)), benzophenones and selected pesticides was assessed by measuring substance specific biomarkers subjected to stringent quality control programs for chemical analysis. For substance groups analyzed in different age groups higher average exposure levels were observed in the youngest age group, i.e., phthalates/DINCH in children versus teenagers, acrylamide and pesticides in children versus adults, and benzophenones in teenagers versus adults. Many biomarkers in teenagers and adults varied significantly according to educational attainment, with higher exposure levels of bisphenols, phthalates, benzophenones, PAHs, and acrylamide in participants (from households) with lower educational attainment, while teenagers from households with higher educational attainment have higher exposure levels for PFASs and arsenic. In children, a social gradient was only observed for the non-specific pyrethroid metabolite 3-PBA and di-isodecyl phthalate (DiDP), with higher levels in children from households with higher educational attainment. Geographical variations were seen for all exposure biomarkers. For 15 biomarkers, the available health-based HBM guidance values were exceeded with the highest exceedance rates for toxicologically relevant arsenic in teenagers (40%), 3-PBA in children (36%), and between 11 and 14% for total DON, Σ (PFOA + PFNA + PFHxS + PFOS), bisphenol S and cadmium. The infrastructure and harmonized approach succeeded in obtaining comparable European-wide internal exposure data for a prioritized set of 11 chemical groups. These data serve as a reference for comparison at the global level, provide a baseline to compare the efficacy of the European Commission's chemical strategy for sustainability, and will give leverage to national policymakers for the implementation of targeted measures.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationGovarts E, Gilles L, Rodriguez Martin L, Santonen T, Apel P, Viegas S, et al. Harmonized human biomonitoring in European children, teenagers and adults: EU-wide exposure data of 11 chemical substance groups from the HBM4EU Aligned Studies (2014-2021). Int J Hyg Environ Health. 2023;249:114119.pt_PT
dc.identifier.doi10.1016/j.ijheh.2023.114119pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/15567
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationHorizon 2020 (grant agreement No 733032)pt_PT
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S143846392300010Xpt_PT
dc.subjectExposure assessmentpt_PT
dc.subjectAdultspt_PT
dc.subjectChildrenpt_PT
dc.subjectExposure biomarkerspt_PT
dc.subjectHBM4EUpt_PT
dc.subjectHuman biomonitoringpt_PT
dc.subjectAdolescentspt_PT
dc.titleHarmonized human biomonitoring in European children, teenagers and adults: EU-wide exposure data of 11 chemical substance groups from the HBM4EU Aligned Studies (2014–2021)pt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.startPage114119pt_PT
oaire.citation.titleInternational Journal of Hygiene and Environmental Healthpt_PT
oaire.citation.volume249pt_PT
person.familyNameViegas
person.givenNameSusana
person.identifier248817
person.identifier.ciencia-idA919-7318-63DC
person.identifier.orcid0000-0003-1015-8760
person.identifier.ridI-4053-2012
person.identifier.scopus-author-id35270591500
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication13115332-43f7-4048-a8a5-2f2b855a8c92
relation.isAuthorOfPublication.latestForDiscovery13115332-43f7-4048-a8a5-2f2b855a8c92

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