Bisphenol A alters transcript levels of biomarker genes for major depressive disorder in vascular endothelial cells and colon cancer cells

Ribeiro-Varandas, Edna; Pereira, H. Sofia; Viegas, Wanda; Delgado, Margarida

http://hdl.handle.net/10400.21/6253

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Authors

Ribeiro-Varandas, Edna

Pereira, H. Sofia

Viegas, Wanda

Delgado, Margarida

Abstract(s)

Bisphenol A (BPA) is capable of mimicking endogenous hormones with potential consequences for human health and BPA exposure has been associated with several human diseases including neuropsychiatric disorders. Here, quantitative Real-Time Polymerase Chain Reaction (qRT-PCR) results show that BPA at low concentrations (10 ng/mL and 1 μg/mL) induces differential transcript levels of four biomarker genes for Major Depressive Disorder (MDD) in HT29 human colon adenocarcinona cell line and Human Umbilical Vein Endothelial Cells (HUVEC). These results substantiate increasing concerns of BPA exposure in levels currently detected in humans.

Keywords

Bisphenol A BPA HUVEC HT29 MDD biomarkers Gene transcription

URI

http://hdl.handle.net/10400.21/6253

Citation

Ribeiro-Varandas E, Pereira HS, Viegas W, Delgado M. Bisphenol A alters transcript levels of biomarker genes for major depressive disorder in vascular endothelial cells and colon cancer cells. Chemosphere. 2016;153:75-7.