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Joint EURADOS-EANM initiative for an advanced computational framework for the assessment of external dose rates from nuclear medicine patients

2024-04Journal article Open access
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dc.contributor.authorStruelens, Lara
dc.contributor.authorHuet, Christelle
dc.contributor.authorBroggio, David
dc.contributor.authorDabin, Jérémie
dc.contributor.authorDesorgher, Laurent
dc.contributor.authorGiussani, Augusto
dc.contributor.authorLi, Wei Bo
dc.contributor.authorNosske, Dietmar
dc.contributor.authorLee, Yi-Kang
dc.contributor.authorCunha, Lidia
dc.contributor.authorRaminhas Carapinha, Maria João
dc.contributor.authorMedvedec, Mario
dc.contributor.authorCovens, Peter
dc.date.accessioned2024-04-26T10:54:42Z
dc.date.available2024-04-26T10:54:42Z
dc.date.issued2024-04
dc.descriptionSome of the authors have received funding for this project from Euratom’s research and innovation program 2019–20 under Grant agreement No. 945196.pt_PT
dc.description.abstractBackground: To ensure adequate radiation protection of critical groups such as staff, caregivers, and the general public coming into proximity of nuclear medicine (NM) patients, it is necessary to consider the impact of the radiation emitted by the patients during their stay at the hospital or after leaving the hospital. Current risk assessments are based on ambient dose rate measurements in a single position at a specified distance from the patient and carried out at several time points after administration of the radiopharmaceutical to estimate the whole-body retention. The limitations of such an approach are addressed in this study by developing and validating a more advanced computational dosimetry approach using Monte Carlo (MC) simulations in combination with flexible and realistic computational phantoms and time activity distribution curves from reference biokinetic models. Results: Measurements of the ambient dose rate equivalent Ḣ*(10) at 1 m from the NM patient have been successfully compared against MC simulations with 5 different codes using the ICRP adult reference computational voxel phantoms, for typical clinical procedures with 99mTc-HDP/MDP, 18FDG and Na131I. All measurement data fall in the 95% confidence intervals, determined for the average simulated results. Moreover, the different MC codes (MCNP-X, PHITS, GATE, GEANT4, TRIPOLI-4®) have been compared for a more realistic scenario where the effective dose rate Ė of an exposed individual was determined in positions facing and aside the patient model at 30 cm, 50 cm, and 100 cm. The variation between codes was lower than 8% for all the radiopharmaceuticals at 1 m and varied from 5 to 16% for the face-to-face and side-by-side configuration at 30 cm and 50 cm. A sensitivity study on the influence of patient model morphology demonstrated that the relative standard deviation of Ḣ*(10) at 1 m for the range of included patient models remained under 16% for time points up to 120 min post-administration. Conclusions: The validated computational approach will be further used for the evaluation of effective dose rates per unit administered activity for a variety of close-contact configurations and a range of radiopharmaceuticals as part of risk assessment studies. Together with the choice of appropriate dose constraints, this would facilitate the setting of release criteria and patient restrictions.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationStruelens L, Huet C, Broggio D, Dabin J, Desorgher L, Carapinha MJ, et al. Joint EURADOS-EANM initiative for an advanced computational framework for the assessment of external dose rates from nuclear medicine patients. EJNMMI Phys. 2024;11:38.pt_PT
dc.identifier.doi10.1186/s40658-024-00638-ypt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/17392
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringerpt_PT
dc.relationEuratom’s research and innovation program 2019–20 under Grant agreement No. 945196.pt_PT
dc.relation.publisherversionhttps://ejnmmiphys.springeropen.com/articles/10.1186/s40658-024-00638-ypt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectNuclear medicinept_PT
dc.subjectNuclear medicine patientspt_PT
dc.subjectCaregiverspt_PT
dc.subjectRelease criteriapt_PT
dc.subjectMonte Carlo simulationpt_PT
dc.subjectComputational modelspt_PT
dc.titleJoint EURADOS-EANM initiative for an advanced computational framework for the assessment of external dose rates from nuclear medicine patientspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.startPage38pt_PT
oaire.citation.titleEJNMMI Physicspt_PT
oaire.citation.volume11pt_PT
person.familyNameRaminhas Carapinha
person.givenNameMaria João
person.identifier.ciencia-idF416-6BAA-D4D7
person.identifier.orcid0000-0002-3343-6500
person.identifier.ridZ-1221-2018
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication406de1e9-dae8-488d-bcdc-fef1da6526a1
relation.isAuthorOfPublication.latestForDiscovery406de1e9-dae8-488d-bcdc-fef1da6526a1

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