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Outcomes of cystoid macular edema following Descemet’s membrane endothelial keratoplasty in a referral center for keratoplasty in Spain: retrospective study

2023-02Journal article Open access
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dc.contributor.authorMoura-Coelho, Nuno
dc.contributor.authorPapa-Vettorazzi, Renato
dc.contributor.authorSantiesteban-García, Imalvet
dc.contributor.authorDias-Santos, Arnaldo
dc.contributor.authorManero, Felicidad
dc.contributor.authorCunha, João Paulo
dc.contributor.authorGüell, José
dc.date.accessioned2023-02-14T12:05:15Z
dc.date.available2023-02-14T12:05:15Z
dc.date.issued2023-02
dc.description.abstractThe aim of this study was to analyze the outcomes of eyes with visually significant cystoid macular œdema (vs-CMO) after Descemet membrane endothelial keratoplasty (DMEK) in a referral center for keratoplasty in Spain. We conducted a retrospective, single-surgeon case series of eyes that developed post-DMEK vs-CMO performed between January 2011 and December 2020. Data collected included: indication for DMEK; biometric data; ocular comorbidities; past medical history; time to detection of vs-CMO after DMEK (T, weeks); best-corrected visual acuity (BCVA, logMAR) and central retinal thickness (CRT, µm) at diagnosis of vs-CMO, after resolution of CMO, and at last follow-up; and management strategy. The main outcomes analyzed were the incidence of vs-CMO and improvement in BCVA and CRT after treatment of vs-CMO. Of 291 consecutive DMEK surgeries, 14 eyes of 13 patients (4.8%) developed vs-CMO. Five patients (38.5%) had a history of CMO, and 28.6% of eyes had ophthalmic comorbidities. Median (P25-P75) T was 4 (3-10) weeks. Treatment success was observed in 12/13 eyes (92.3%), two of which required second-line treatment. In successful cases (median time-to-resolution 3.0 (2.0-3.5) months), median BCVA improved from 0.60 (0.40-0.80) logMAR to 0.30 (0.15-0.40) logMAR (p = 0.002) after treatment, and median CRT improved from 582.5 (400.0-655.0) µm to 278.0 (258.0-294.0) µm (p = 0.005). In our study, we found a 4.8% rate of post-DMEK vs-CMO, with most cases occurring in the first 3 months after surgery. Good functional and anatomical outcomes are expected in most eyes, without treatment-related complications or implications in graft outcomes. Additional studies are encouraged to determine a standardized protocol for post-DMEK vs-CMO.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMoura-Coelho N, Papa-Vettorazzi R, Santiesteban-García I, Dias-Santos A, Manero F, Cunha JP, et al. Outcomes of cystoid macular edema following Descemet's membrane endothelial keratoplasty in a referral center for keratoplasty in Spain: retrospective study. Sci Rep. 2023;13(1):2375.pt_PT
dc.identifier.doi10.1038/s41598-023-29127-5pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/15568
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringer Naturept_PT
dc.relation.publisherversionhttps://www.nature.com/articles/s41598-023-29127-5pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectOphthalmologypt_PT
dc.subjectDescemet membranept_PT
dc.subjectDescemet stripping endothelial keratoplastypt_PT
dc.subjectCorneal endotheliumpt_PT
dc.subjectTransplantationpt_PT
dc.subjectFuchs' endothelial dystrophypt_PT
dc.subjectMacular edemapt_PT
dc.subjectSpainpt_PT
dc.titleOutcomes of cystoid macular edema following Descemet’s membrane endothelial keratoplasty in a referral center for keratoplasty in Spain: retrospective studypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue1pt_PT
oaire.citation.startPage2375pt_PT
oaire.citation.titleScientific Reportspt_PT
oaire.citation.volume13pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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