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Cobalt and Zinc Compounds Bearing 1,10-Phenanthroline-5,6-dione or 1,3,5-Triaza-7-phosphaadamantane Derivatives - Synthesis, Characterization, Cytotoxicity, and Cell Selectivity Studies

2013-07Journal article Open access
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dc.contributor.authorSilva, Telma F. S.
dc.contributor.authorSmolenski, Piotr
dc.contributor.authorMartins, Luisa
dc.contributor.authorGuedes Da Silva, M. Fátima C.
dc.contributor.authorFernandes, Alexandra R.
dc.contributor.authorLuis, Daniel
dc.contributor.authorSilva, Ana
dc.contributor.authorSantos, Susana
dc.contributor.authorBorralho, Pedro M.
dc.contributor.authorRodrigues, Cecilia M. P.
dc.contributor.authorPombeiro, Armando
dc.date.accessioned2013-11-02T18:42:08Z
dc.date.available2013-11-02T18:42:08Z
dc.date.issued2013-07
dc.description.abstractThe compounds [mPTA][CoCl4] (1, mPTA = N-methyl-1,3,5-triaza-7-phosphaadamantane cation), [CoCl(H2O)(DION)(2)][BF4] (2, DION = 1,10-phenanthroline-5,6-dione), [Zn(DION)(2)]Cl-2 (3) and [ZnCl(O-PTA=O)(DION)][BF4] (4) were synthesized by reaction of CoCl2 with [mPTA]I or DION and ZnCl2 with DION or 1,3,5-triaza-7-phosphaadamantane-7-oxide (PTA=O) and DION, respectively. All complexes are water soluble and have been characterized by IR, far-IR, H-1, C-13 and P-31{H-1} NMR spectroscopy, ESI-MS, elemental analyses and single-crystal X-ray diffraction structural analysis (for 1). They were screened against the human tumour cell lines HCT116, HepG2 and MCF7. Complexes 2 and 3 exhibit the highest in vitro cytotoxicity and show lower cytotoxic activities in normal human fibroblast cell line than in HCT116 tumour cell line, which demonstrates their slight specificity for this type of tumour cell.por
dc.identifier.citationSILVA, Telma F. S.; SMOLENSKI, Piotr; MARTINS, Luisa M. D. R. S.; GUEDES DA SILVA, M. Fatima C.; FERNANDES, Alexandra R.; LUIS, Daniel; SILVA Ana; SANTOS, Susana; BORRALHO, Pedro M.; RODRIGUES, Cecilia M. P.; POMBEIRO, Armando J. L. - Cobalt and Zinc Compounds Bearing 1,10-Phenanthroline-5,6-dione or 1,3,5-Triaza-7-phosphaadamantane Derivatives - Synthesis, Characterization, Cytotoxicity, and Cell Selectivity Studies. European Journal of Inorganic Chemistry. ISSN 1434-1948. Vol. 2013, nr. 21 (2013), p. 3651-3658.por
dc.identifier.issn1434-1948
dc.identifier.other10.1002/ejic.201300197
dc.identifier.urihttp://hdl.handle.net/10400.21/2844
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherWiley-V C H Verlag GMBHpor
dc.subjectCobaltpor
dc.subjectZincpor
dc.subjectN ligandspor
dc.subjectMedicinal chemistrypor
dc.subjectAntitumor agentspor
dc.subjectTransition-metal-complexespor
dc.subjectIn-vitro cytotoxicitypor
dc.subjectRay crystal-structurepor
dc.subjectWater-soluble PTApor
dc.subjectCoordination chemistrypor
dc.subjectSuperoxide-dismutasepor
dc.subjectAnticancer activitypor
dc.subjectLigandspor
dc.subject1STpor
dc.subjectDrugspor
dc.titleCobalt and Zinc Compounds Bearing 1,10-Phenanthroline-5,6-dione or 1,3,5-Triaza-7-phosphaadamantane Derivatives - Synthesis, Characterization, Cytotoxicity, and Cell Selectivity Studiespor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.conferencePlaceWeinheimpor
oaire.citation.endPage3658por
oaire.citation.issue21por
oaire.citation.startPage3651por
oaire.citation.titleEuropean Journal of Inorganic Chemistrypor
oaire.citation.volume2013por
person.familyNameSmolenski
person.familyNameMartins
person.familyNameGuedes da Silva
person.familyNamePombeiro
person.givenNamePiotr
person.givenNameLuisa
person.givenNameM. Fátima C.
person.givenNameArmando
person.identifier772058
person.identifier637885
person.identifier789079
person.identifier.ciencia-id3119-4D49-A268
person.identifier.ciencia-idE218-E297-A4EA
person.identifier.ciencia-id7619-8E8E-979A
person.identifier.ciencia-id8311-38FA-CEFB
person.identifier.orcid0000-0001-5969-6012
person.identifier.orcid0000-0002-5403-9352
person.identifier.orcid0000-0003-4836-2409
person.identifier.orcid0000-0001-8323-888X
person.identifier.ridG-6210-2011
person.identifier.ridH-8274-2012
person.identifier.ridI-5945-2012
person.identifier.scopus-author-id23091814400
person.identifier.scopus-author-id8650947800
person.identifier.scopus-author-id6701761571
person.identifier.scopus-author-id7006067269
rcaap.rightsrestrictedAccesspor
rcaap.typearticlepor
relation.isAuthorOfPublication462852fa-ba94-4430-a4f9-ba1a1a22e130
relation.isAuthorOfPublication8ed70b09-b4d3-4a5d-9f75-12b13a332204
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relation.isAuthorOfPublication6d18ff2e-5c33-4010-b1e7-964c72349813
relation.isAuthorOfPublication.latestForDiscovery18e14ad3-9937-46d0-83b2-36fab224c1c0

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