Cobalt and Zinc Compounds Bearing 1,10-Phenanthroline-5,6-dione or 1,3,5-Triaza-7-phosphaadamantane Derivatives - Synthesis, Characterization, Cytotoxicity, and Cell Selectivity Studies

Silva, Telma F. S.; Smolenski, Piotr; Martins, Luisa; Guedes Da Silva, M. Fátima C.; Fernandes, Alexandra R.; Luis, Daniel; Silva, Ana; Santos, Susana; Borralho, Pedro M.; Rodrigues, Cecilia M. P.; Pombeiro, Armando

http://hdl.handle.net/10400.21/2844

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Authors

Silva, Telma F. S.

Smolenski, Piotr

Martins, Luisa

Guedes Da Silva, M. Fátima C.

Fernandes, Alexandra R.

Rodrigues, Cecilia M. P.

Abstract(s)

The compounds [mPTA][CoCl4] (1, mPTA = N-methyl-1,3,5-triaza-7-phosphaadamantane cation), [CoCl(H2O)(DION)(2)][BF4] (2, DION = 1,10-phenanthroline-5,6-dione), [Zn(DION)(2)]Cl-2 (3) and [ZnCl(O-PTA=O)(DION)][BF4] (4) were synthesized by reaction of CoCl2 with [mPTA]I or DION and ZnCl2 with DION or 1,3,5-triaza-7-phosphaadamantane-7-oxide (PTA=O) and DION, respectively. All complexes are water soluble and have been characterized by IR, far-IR, H-1, C-13 and P-31{H-1} NMR spectroscopy, ESI-MS, elemental analyses and single-crystal X-ray diffraction structural analysis (for 1). They were screened against the human tumour cell lines HCT116, HepG2 and MCF7. Complexes 2 and 3 exhibit the highest in vitro cytotoxicity and show lower cytotoxic activities in normal human fibroblast cell line than in HCT116 tumour cell line, which demonstrates their slight specificity for this type of tumour cell.

Keywords

Cobalt Zinc N ligands Medicinal chemistry Antitumor agents Transition-metal-complexes In-vitro cytotoxicity Ray crystal-structure Water-soluble PTA Coordination chemistry Superoxide-dismutase Anticancer activity Ligands 1ST Drugs

URI

http://hdl.handle.net/10400.21/2844

Citation

SILVA, Telma F. S.; SMOLENSKI, Piotr; MARTINS, Luisa M. D. R. S.; GUEDES DA SILVA, M. Fatima C.; FERNANDES, Alexandra R.; LUIS, Daniel; SILVA Ana; SANTOS, Susana; BORRALHO, Pedro M.; RODRIGUES, Cecilia M. P.; POMBEIRO, Armando J. L. - Cobalt and Zinc Compounds Bearing 1,10-Phenanthroline-5,6-dione or 1,3,5-Triaza-7-phosphaadamantane Derivatives - Synthesis, Characterization, Cytotoxicity, and Cell Selectivity Studies. European Journal of Inorganic Chemistry. ISSN 1434-1948. Vol. 2013, nr. 21 (2013), p. 3651-3658.