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Clinical, serological and DNA testing in Bengo Province, Angola further reveals low filarial endemicity and opportunities for disease elimination

2020-11Journal article Open access
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dc.contributor.authorPaulo, Rossely
dc.contributor.authorBrito, Miguel
dc.contributor.authorVan-Dunem, Pedro
dc.contributor.authorMartins, António
dc.contributor.authorNovak, Robert J.
dc.contributor.authorJacob, Benjamin
dc.contributor.authorMolyneux, David M.
dc.contributor.authorUnnasch, Thomas R.
dc.contributor.authorStothard, J. Russell
dc.contributor.authorKelly-Hope, Louise
dc.date.accessioned2020-10-15T14:48:51Z
dc.date.available2020-10-15T14:48:51Z
dc.date.issued2020-11
dc.description.abstractThe prevalence of Loa loa, Onchocerca volvulus, and Wuchereria bancrofti infections in an under-surveyed area of Bengo Province, Angola, was determined by surveying 22 communities with a combination of clinical, serological, and DNA diagnostics. Additional information was collected on participants' duration of residency, access to mass drug administration, knowledge of insect vectors, and use of bednets. A total of 1616 individuals (38.1% male: 61.9% female), with an average age of 43 years, were examined. For L. loa, 6.2% (n = 100/16616) individuals were found to have eyeworm, based on the rapid assessment procedure for loiasis (RAPLOA) surveys, and 11.5% (n =178/1543) based on nested PCR analyses of venous blood. L. loa prevalences in long-term residents (>10 years) and older individuals (>60 years) were significantly higher, and older men with eyeworm were better informed about Chrysops vectors. For O. volvulus, 4.7% (n = 74/1567) individuals were found to be positive by enzyme-linked immunosorbent assay (Ov 16 ELISA), with only three individuals reporting to have ever taken ivermectin. For W. bancrofti, no infections were found using the antigen-based immunochromatographic test (ICT) and real-time PCR analysis; however, 27 individuals presented with lymphatic filariasis (LF) related clinical conditions (lymphoedema = 11, hydrocoele = 14, both = 2). Just under half (45.5%) of the participants owned a bednet, with the majority (71.1%) sleeping under it the night before. Our approach of using combination diagnostics reveals the age-prevalence of loiasis alongside low endemicity of onchocerciasis and LF. Future research foci should be on identifying opportunities for more cost-effective ways to eliminate onchocerciasis and to develop innovative surveillance modalities for clinical LF for individual disease management and disability prevention.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationPaulo R, Brito M, Van-Dunem P, Martins A, Novak RJ, Jacob B, et al. Clinical, serological and DNA testing in Bengo Province, Angola further reveals low filarial endemicity and opportunities for disease elimination. Parasite Epidemiol Control. 2020;11:e00183.pt_PT
dc.identifier.doi10.1016/j.parepi.2020.e00183pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/12288
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S2405673120300520?via%3Dihubpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectLoiasispt_PT
dc.subjectChrysopspt_PT
dc.subjectOnchocerciasispt_PT
dc.subjectLymphatic filariasispt_PT
dc.subjectCo-infectionpt_PT
dc.subjectMappingpt_PT
dc.subjectDNA testingpt_PT
dc.subjectAngolapt_PT
dc.subjectProvíncia do Bengopt_PT
dc.titleClinical, serological and DNA testing in Bengo Province, Angola further reveals low filarial endemicity and opportunities for disease eliminationpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.startPagee00183pt_PT
oaire.citation.titleParasite Epidemiology and Controlpt_PT
oaire.citation.volume11pt_PT
person.familyNameBrito
person.givenNameMiguel
person.identifier.ciencia-id231F-F341-7E93
person.identifier.orcid0000-0001-6394-658X
person.identifier.ridA-7970-2016
person.identifier.scopus-author-id35224551000
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication4252d8e0-800c-4d67-8b13-0b711d860669
relation.isAuthorOfPublication.latestForDiscovery4252d8e0-800c-4d67-8b13-0b711d860669

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