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Association of FTO and PPARG polymorphisms with obesity in Portuguese women

2013-07Journal article Open access
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dc.contributor.authorCarlos, Fábio Ferreira
dc.contributor.authorSilva-Nunes, José
dc.contributor.authorFlores, Orfeu
dc.contributor.authorBrito, Miguel
dc.contributor.authorDoria, Gonçalo
dc.contributor.authorVeiga, Luísa
dc.contributor.authorBaptista, Pedro Viana
dc.date.accessioned2013-10-24T15:02:37Z
dc.date.available2013-10-24T15:02:37Z
dc.date.issued2013-07
dc.description.abstractPurpose: We evaluated the association between risk of obesity in the Portuguese population and two obesity-related single-nucleotide gene polymorphisms: fat-mass and obesity-associated (FTO) rs9939609 and peroxisome proliferator-activated receptor gamma (PPARG) rs1801282. Patients and methods: A total of 194 Portuguese premenopausal female Caucasians aged between 18 and 50 years (95 with body mass index [BMI] ≥30 g/m2, 99 controls with BMI 18.5–24.9 kg/m2) participated in this study. The association of the single-nucleotide polymorphisms with obesity was determined by odds ratio calculation with 95% confidence intervals. Results: Significant differences in allelic expression of FTO rs9939609 (P<0.05) were found between control and case groups, indicating a 2.5-higher risk for obesity in the presence of both risk alleles when comparing the control group with the entire obese group. A fourfold-higher risk was found for subjects with class III obesity compared to those with classes I and II. No significant differences in BMI were found between the control and case groups for PPARG rs1801282 (P>0.05). Conclusion: For the first time, a study involving an adult Portuguese population shows that individuals harboring both risk alleles in the FTO gene locus are at higher risk for obesity, which is in agreement to what has been reported for other European populations.por
dc.identifier.citationCarlos FF, Silva-Nunes J, Flores O, Brito M, Doria G, Veiga L, Baptista PV. Association of FTO and PPARG polymorphisms with obesity in Portuguese women. Diabetes Metab Syndr Obes. 2013;6:241-5.por
dc.identifier.issn1178-7007
dc.identifier.urihttp://hdl.handle.net/10400.21/2774
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherDove Presspor
dc.relation.publisherversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3712741/por
dc.subjectObesitypor
dc.subjectWomenpor
dc.subjectPPARG polymorphismspor
dc.subjectFTO polymorphismspor
dc.subjectrs9939609por
dc.subjectrs1801282por
dc.subjectBMIpor
dc.subjectSNPpor
dc.subjectOdds ratiopor
dc.subjectPortugalpor
dc.titleAssociation of FTO and PPARG polymorphisms with obesity in Portuguese womenpor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage245por
oaire.citation.startPage241por
oaire.citation.titleDiabetes, Metabolic Syndrome and Obesitypor
oaire.citation.volume6por
person.familyNameBrito
person.familyNameVeiga
person.givenNameMiguel
person.givenNameLuisa
person.identifier.ciencia-id231F-F341-7E93
person.identifier.ciencia-id9413-918D-DB0E
person.identifier.orcid0000-0001-6394-658X
person.identifier.orcid0000-0003-1153-8343
person.identifier.ridA-7970-2016
person.identifier.ridL-2730-2013
person.identifier.scopus-author-id35224551000
person.identifier.scopus-author-id8318978600
rcaap.rightsopenAccesspor
rcaap.typearticlepor
relation.isAuthorOfPublication4252d8e0-800c-4d67-8b13-0b711d860669
relation.isAuthorOfPublicationaac1914a-275f-4be2-819d-ab41d356b45a
relation.isAuthorOfPublication.latestForDiscoveryaac1914a-275f-4be2-819d-ab41d356b45a

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