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Effects of exposure to formaldehyde and tobacco smoking on genotoxicity biomarkers

dc.contributor.authorLadeira, Carina
dc.contributor.authorGomes, Manuel C.
dc.contributor.authorBrito, Miguel
dc.date.accessioned2011-11-28T10:59:50Z
dc.date.available2011-11-28T10:59:50Z
dc.date.issued2011-09
dc.description.abstractFormaldehyde (FA) is a colour less gas widely used in the industry and hospitals as an aqueous solution, formalin. It is extremely reactive and induces various genotoxic effects in proliferating cultured mammalian cells. Tobacco smoke has been epidemiologically associated to a higher risk of development of cancer, especially in the oral cavity, larynx and lungs, as these are places of direct contact with many carcinogenic tobacco’s compounds. Approximately 90% of human cancers originate from epithelial cells. Therefore, it could be argued that oral epithelial cells represent a preferred target site for early genotoxic events induced by carcinogenic agents entering the body via inhalation and ingestion. The cytokinesis-blocked micronucleus assay (CBMN) in human lymphocytes is one of the most commonly used methods for measuring DNA damage, namely the detection of micronucleus, nucleoplasmic bridges, and nuclear buds.por
dc.identifier.citationLadeira C, Gomes MC, Brito M. Effects of exposure to formaldehyde and tobacco smoking on genotoxicity biomarkers. In The European Environmental Mutagens Society, Oslo (Norway), 15th to 18th September 2011. Poster.por
dc.identifier.urihttp://hdl.handle.net/10400.21/649
dc.language.isoengpor
dc.peerreviewedyespor
dc.subjectAnatomia patológicapor
dc.subjectSaúde ocupacionalpor
dc.subjectFormaldeídopor
dc.subjectTabagismopor
dc.subjectBiomarcador tumoralpor
dc.titleEffects of exposure to formaldehyde and tobacco smoking on genotoxicity biomarkerspor
dc.typeconference object
dspace.entity.typePublication
person.familyNameLadeira
person.familyNameBrito
person.givenNameCarina
person.givenNameMiguel
person.identifier144237
person.identifier.ciencia-id801C-1BBA-1D9E
person.identifier.ciencia-id231F-F341-7E93
person.identifier.orcid0000-0001-5588-0074
person.identifier.orcid0000-0001-6394-658X
person.identifier.ridJ-2572-2012
person.identifier.ridA-7970-2016
person.identifier.scopus-author-id36463788000
person.identifier.scopus-author-id35224551000
rcaap.rightsopenAccesspor
rcaap.typeconferenceObjectpor
relation.isAuthorOfPublication1aef4b60-4197-436b-84ab-80d31cbaed33
relation.isAuthorOfPublication4252d8e0-800c-4d67-8b13-0b711d860669
relation.isAuthorOfPublication.latestForDiscovery4252d8e0-800c-4d67-8b13-0b711d860669

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