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Advisor(s)
Abstract(s)
Formaldehyde (FA) is a colour less gas widely used in the industry and hospitals as an aqueous solution, formalin. It is extremely reactive and induces various genotoxic effects in proliferating cultured mammalian cells. Tobacco smoke has been epidemiologically associated to a higher risk of development of cancer, especially in the oral cavity, larynx and lungs, as these are places of direct contact with many carcinogenic tobacco’s compounds. Approximately 90% of human cancers originate from epithelial cells. Therefore, it could be argued that oral epithelial cells represent a preferred target site for early genotoxic events induced by carcinogenic agents entering the body via inhalation and ingestion. The cytokinesis-blocked micronucleus assay (CBMN) in human lymphocytes is one of the most commonly used methods for measuring DNA damage, namely the detection of micronucleus, nucleoplasmic bridges, and nuclear buds.
Description
Keywords
Anatomia patológica Saúde ocupacional Formaldeído Tabagismo Biomarcador tumoral
Citation
Ladeira C, Gomes MC, Brito M. Effects of exposure to formaldehyde and tobacco smoking on genotoxicity biomarkers. In The European Environmental Mutagens Society, Oslo (Norway), 15th to 18th September 2011. Poster.