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Concordance between FVC and FEV<sub>6</sub> for identifying chronic airflow obstruction and spirometric restriction in the Burden of Obstructive Lung Disease (BOLD) study

2025-07Journal article Open access
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datacite.subject.sdg03:Saúde de Qualidade
dc.contributor.authorKnox-Brown, Ben
dc.contributor.authorPotts, James
dc.contributor.authorFranssen, Frits M. E.
dc.contributor.authorNielsen, Rune
dc.contributor.authorDenguezli, Meriem
dc.contributor.authorRotevatn, Anders Ørskov
dc.contributor.authorJuvekar, Sanjay K.
dc.contributor.authorCherkaski, Hamid Hacene
dc.contributor.authorStudnicka, Michael
dc.contributor.authorSylvester, Karl Peter
dc.contributor.authorMortimer, Kevin
dc.contributor.authorBateman, Eric D.
dc.contributor.authorJanson, Christer
dc.contributor.authorMalinovschi, Andrei
dc.contributor.authorSeemungal, Terence
dc.contributor.authorKoul, Parvaiz
dc.contributor.authorMannino, David
dc.contributor.authorMahesh, Padukudru Anand
dc.contributor.authorJogi, Rain
dc.contributor.authorMejza, Filip
dc.contributor.authorAl Ghobain, Mohammed
dc.contributor.authorParaguas, Stefanni Nonna M.
dc.contributor.authorWelte, Tobias
dc.contributor.authorWouters, Eliel
dc.contributor.authorGislason, Thorarinn
dc.contributor.authorHarrabi, Imed
dc.contributor.authorDias, Maria Hermínia Monteiro Brites
dc.contributor.authorObaseki, Daniel O.
dc.contributor.authorKocabas, Ali
dc.contributor.authorBarbara, Cristina
dc.contributor.authorCardoso, João
dc.contributor.authorAgarwal, Dhiraj
dc.contributor.authorNafees, Asaad Ahmed
dc.contributor.authorRodrigues, Fatima
dc.contributor.authorGarcia-Larsen, Vanessa
dc.contributor.authorErhabor, Gregory E.
dc.contributor.authorLoh, Li-Cher
dc.contributor.authorAmaral, Andre F. S.
dc.date.accessioned2025-09-02T11:02:24Z
dc.date.available2025-09-02T11:02:24Z
dc.date.issued2025-07
dc.descriptionUK Research and Innovation UK Medical Research Council: MR/ R011192/1 and Wellcome Trust: 085790/Z/08/Z.
dc.description.abstractIntroduction: We investigated whether the forced expiratory volume in 6 s (FEV6) can be used as a surrogate for the forced vital capacity (FVC). Methods: The Burden of Obstructive Lung Disease is a multinational cohort study. At baseline, data were collected from adults aged 40 years or older, from 41 sites across 34 countries. Participants from 18 sites were followed up after a median of 8.3 years. Participants who completed the study core questionnaire and had acceptable post-bronchodilator spirometry were included. We performed receiver operating characteristic analyses to measure the ability of FEV1/FEV6 less than the lower limit of normal (LLN) to correctly classify FEV1/FVC less than the LLN, and FEV6 less than the LLN to correctly classify FVC less than the LLN. We used multilevel regression analyses to assess the association of discordant measurements with respiratory symptoms, quality of life, and lung function decline. Results: At baseline, 28,604 participants were included. 53% were female (15,060). 10% (2876) had chronic airflow obstruction for FEV1/FVC, compared with 9% (2704) for FEV1/FEV6. 37% (10,637) had spirometric restriction for FVC, compared with 35% (9978) for FEV6. The FEV1/FEV6 had excellent accuracy in identifying FEV1/FVC less than the LLN (area under the curve (AUC): 0.90, 95% CI, 0.89 to 0.91, κ coefficient 0.82). The FEV6 also had excellent agreement in identifying FVC less than the LLN (AUC: 0.95, 95% CI, 0.94 to 0.95, κ coefficient 0.90). Discordant reductions in FEV1/FEV6 (1%, 345) and FEV6 (1%, 309) were associated with greater odds of having respiratory symptoms and a lower physical quality of life. 3870 participants were followed up with. Those with discordant reductions in FEV1/FEV6 and FEV6 were more likely to have chronic airflow obstruction and spirometric restriction at follow-up. Conclusions: There is strong agreement between the FVC and FEV6 in the identification of chronic airflow obstruction and spirometric restriction.eng
dc.identifier.citationKnox-Brown B, Potts J, Franssen FM, Nielsen R, Denguezli M, Dias H, et al.; BOLD collaborative research group. Concordance between FVC and FEV6 for identifying chronic airflow obstruction and spirometric restriction in the Burden of Obstructive Lung Disease (BOLD) study. BMJ Open Respir Res. 2025;12(1):e002355.
dc.identifier.doi10.1136/bmjresp-2024-002355
dc.identifier.issn2052-4439
dc.identifier.urihttp://hdl.handle.net/10400.21/22088
dc.language.isoeng
dc.peerreviewedyes
dc.publisherBMJ Publishing Group
dc.relation.hasversionhttps://bmjopenrespres.bmj.com/content/12/1/e002355
dc.relation.ispartofBMJ Open Respiratory Research
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectClinical epidemiology
dc.subjectLung physiology
dc.subjectRespiratory function test
dc.subjectRespiratory measurement
dc.subjectSensitivity
dc.subjectSpecificity
dc.titleConcordance between FVC and FEV<sub>6</sub> for identifying chronic airflow obstruction and spirometric restriction in the Burden of Obstructive Lung Disease (BOLD) studyeng
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue1
oaire.citation.startPagee002355
oaire.citation.titleBMJ Open Respiratory Research
oaire.citation.volume12
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameDias
person.givenNameMaria Hermínia Monteiro Brites
person.identifier.orcid0000-0003-1257-8734
relation.isAuthorOfPublication4ba812bb-8b70-4413-af7a-91e0f04cbad7
relation.isAuthorOfPublication.latestForDiscovery4ba812bb-8b70-4413-af7a-91e0f04cbad7

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