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Orientador(es)
Resumo(s)
Biomedical research, like any other research field, is vulnerable to problems in its planning, execution, documentation, analysis, interpretation, and reporting. These issues can impede the reproducibility of research findings and hinder translation into clinical practice. In addition, there is growing societal pressure to hasten the shift to animal-free research methods. To alleviate the ethical dilemma of using animals in research, the 3Rs principle (replace, reduce, refine) calls for reducing or replacing such experiments wherever possible. Nevertheless, scientific and biomedical research, as well as safeguarding human and environmental health, continue to depend on animal experiments. To apply the 3Rs principles without compromising scientific progress and safety standards, it is imperative to ensure that in vitro methods to replace animal experiments are robust and reliable.
Descrição
This publication is based upon work from the working group Quality and Translatability of Science within the COST Action IMPROVE (“3Rs concepts to improve the quality of biomedical science”), CA21139, supported by European Cooperation in Science and Technology (COST, www.cost.eu).
Palavras-chave
Research Transparency Reproducibility Pregistration
Contexto Educativo
Citação
Heinl C, Franco NH, Bert B, Siewert K, Movia D, Ladeira C, et al. A call for preregistration of in vitro research: pregistration as a tool to improve reproducibility and transparency. EMBO Rep. 2026 Apr 17. Epub ahead of print.
Editora
Springer Science and Business Media LLC