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Quantification methods for 99mTc-labelled disphosphonates uptake in cardiac amyloidosis

2025-12Artigo científico Acesso aberto
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datacite.subject.sdg03:Saúde de Qualidade
dc.contributor.authorFerreira, José Manuel Belo
dc.contributor.authorNeves, Matilde Sousa
dc.contributor.authorFigueiredo, Sérgio
dc.date.accessioned2026-01-06T09:58:33Z
dc.date.available2026-01-06T09:58:33Z
dc.date.issued2025-12
dc.description.abstractIntroduction: Bone scintigraphy (BS) has emerged as a non-invasive technique of increasing importance in the diagnosis of transthyretin cardiac amyloidosis (CA). The most commonly used approaches include visual grading and semi-quantitative analysis. However, these techniques are limited by operator dependence and subjectivity in interpretation. To address these challenges, absolute quantification techniques are being explored to enhance diagnostic accuracy and consistency and to minimize interobserver variability. The objective is to identify the quantification methods currently employed in the assessment of CA. Material and methods: A systematic review was conducted, including 12 articles retrieved from Scopus, PubMed, and Web of Science databases. Studies published in the last 5 years were selected, focusing on quantification methods applied to planar imaging and single-photon emission computed tomography combined with computed tomography (SPECT/CT) in the context of CA. Results: All 12 selected studies (100%) utilized visual grading; semi-quantitative methods were reported in 91.7% of studies, while absolute quantification techniques were applied in 33.3%. Among the semi-quantitative methods, the heart-to-contralateral lung (H/CL) ratio was the most commonly reported, with similar cut-off values (± 1.5) in the different articles. Additional ratios [heart-to-rib (H/R), heart-to-whole-body (H/WB), heart-to-pelvis (H/P), ratio of heart-to-thigh (RHT)] appeared less frequently, though they were investigated as alternative diagnostic markers. Absolute quantification methods reported heterogeneous cut- -off thresholds, ranging from 1.25 to 6.1, based on standardized uptake values (SUVs), to discriminate between individuals with and without CA. Conclusions: Visual grading remains the clinical standard approach. The H/CL ratio is the most reported semi-quantitative method, although it presents some limitations. Absolute quantification with SPECT/CT (SUVmax, SUVpeak) is promising for diagnosis, prognosis, and monitoring of transthyretin amyloidosis (ATTR) CA, yet consensus reference values are lacking.eng
dc.identifier.citationFerreira JM, Neves MS, Figueiredo SR. Quantification methods for 99mTc-labelled disphosphonates uptake in cardiac amyloidosis. Nucl Med Rev Cent East Eur. 2025;28:118-27.
dc.identifier.doi10.5603/nmr.107884
dc.identifier.issn1644-4345
dc.identifier.issn1506-9680
dc.identifier.urihttp://hdl.handle.net/10400.21/22435
dc.language.isoeng
dc.peerreviewedyes
dc.publisherVia Medica Medical Publishers
dc.relation.hasversionhttps://journals.viamedica.pl/nuclear_medicine_review/article/view/107884
dc.relation.ispartofNuclear Medicine Review
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectNuclear medicine
dc.subjectSPECT-CT
dc.subjectAbsolute quantification
dc.subjectBone scintigraphy
dc.subjectCardiac amyloidosis
dc.subjectPlanar-body imaging
dc.subjectWhole-body imaging
dc.subjectSemi-quantification
dc.subjectTransthyretin amyloidosis
dc.subjectVisual score
dc.titleQuantification methods for 99mTc-labelled disphosphonates uptake in cardiac amyloidosiseng
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage127
oaire.citation.issue0
oaire.citation.startPage118
oaire.citation.titleNuclear Medicine Review. Central & Eastern Europe
oaire.citation.volume28
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85

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