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DNA damage in circulating leukocytes measured with the comet assay may predict the risk of death

2021-08Journal article Open access
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dc.contributor.authorBonassi, Stefano
dc.contributor.authorCeppi, Marcello
dc.contributor.authorMøller, Peter
dc.contributor.authorAzqueta, Amaya
dc.contributor.authorMilić, Mirta
dc.contributor.authorMonica, Neri
dc.contributor.authorBrunborg, Gunnar
dc.contributor.authorGodschalk, Roger
dc.contributor.authorKoppen, Gudrun
dc.contributor.authorLangie, Sabine A. S.
dc.contributor.authorTeixeira, João Paulo
dc.contributor.authorBruzzone, Marco
dc.contributor.authorDa Silva, Juliana
dc.contributor.authorBenedetti, Danieli
dc.contributor.authorCavallo, Delia
dc.contributor.authorUrsini, Cinzia Lucia
dc.contributor.authorGiovannelli, Lisa
dc.contributor.authorMoretti, Silvia
dc.contributor.authorRiso, Patrizia
dc.contributor.authorDel Bo’, Cristian
dc.contributor.authorRusso, Patrizia
dc.contributor.authorDobrzyńska, Malgorzata
dc.contributor.authorGoroshinskaya, Irina A.
dc.contributor.authorSurikova, Ekaterina I.
dc.contributor.authorStaruchova, Marta
dc.contributor.authorBarančokova, Magdalena
dc.contributor.authorVolkovova, Katarina
dc.contributor.authorKažimirova, Alena
dc.contributor.authorSmolkova, Bozena
dc.contributor.authorLaffon, Blanca
dc.contributor.authorValdiglesias, Vanessa
dc.contributor.authorPastor, Susana
dc.contributor.authorMarcos, Ricard
dc.contributor.authorHernández, Alba
dc.contributor.authorGajski, Goran
dc.contributor.authorSpremo-Potparević, Biljana
dc.contributor.authorŽivković, Lada
dc.contributor.authorBoutet-Robinet, Elisa
dc.contributor.authorPerdry, Hervé
dc.contributor.authorLebailly, Pierre
dc.contributor.authorPerez, Carlos L.
dc.contributor.authorBasaran, Nursen
dc.contributor.authorNemeth, Zsuzsanna
dc.contributor.authorSafar, Anna
dc.contributor.authorDusinska, Maria
dc.contributor.authorCollins, Andrew
dc.contributor.authorAnderson, Diana
dc.contributor.authorAndrade, Vanessa
dc.contributor.authorPereira, Cristiana Costa
dc.contributor.authorCosta, Solange
dc.contributor.authorGutzkow, Kristine B.
dc.contributor.authorLadeira, Carina
dc.contributor.authorMoretti, Massimo
dc.contributor.authorCosta, Carla
dc.contributor.authorOrlow, Irene
dc.contributor.authorRojas, Emilio
dc.contributor.authorPourrut, Bertrand
dc.contributor.authorKruszewski, Marcin
dc.contributor.authorKnasmueller, Siegfried
dc.contributor.authorShaposhnikov, Sergey
dc.contributor.authorŽegura, Bojana
dc.contributor.authorStopper, Helga
dc.date.accessioned2021-09-02T17:25:34Z
dc.date.available2021-09-02T17:25:34Z
dc.date.issued2021-08
dc.description.abstractThe comet assay or single cell gel electrophoresis is the most common method used to measure strand breaks and a variety of other DNA lesions in human populations. To estimate the risk of overall mortality, mortality by cause, and cancer incidence associated with DNA damage, a cohort of 2,403 healthy individuals (25,978 person-years) screened in 16 laboratories using the comet assay between 1996 and 2016 was followed-up. Kaplan–Meier analysis indicated a worse overall survival in the medium and high tertile of DNA damage (p < 0.001). The effect of DNA damage on survival was modeled according to Cox proportional hazard regression model. The adjusted hazard ratio (HR) was 1.42 (1.06–1.90) for overall mortality and 1.94 (1.04–3.59) for diseases of the circulatory system in subjects with the highest tertile of DNA damage. The findings of this study provide epidemiological evidence encouraging the implementation of the comet assay in preventive strategies for non-communicable diseases.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationBonassi S, Ceppi M, Møller P, Azqueta A, Milić M, Ladeira C, et al. DNA damage in circulating leukocytes measured with the comet assay may predict the risk of death. Sci Rep. 2021;11:16793.pt_PT
dc.identifier.doi10.1038/s41598-021-95976-7pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/13667
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherNaturept_PT
dc.relationCOST Action CA15132 (hCOMET)pt_PT
dc.relation.publisherversionhttps://www.nature.com/articles/s41598-021-95976-7pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectBiomarkerspt_PT
dc.subjectRisk factorpt_PT
dc.subjectDNA damagept_PT
dc.subjectComet assaypt_PT
dc.titleDNA damage in circulating leukocytes measured with the comet assay may predict the risk of deathpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.startPage16793pt_PT
oaire.citation.titleScientific Reportspt_PT
oaire.citation.volume11pt_PT
person.familyNameLadeira
person.givenNameCarina
person.identifier144237
person.identifier.ciencia-id801C-1BBA-1D9E
person.identifier.orcid0000-0001-5588-0074
person.identifier.ridJ-2572-2012
person.identifier.scopus-author-id36463788000
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication1aef4b60-4197-436b-84ab-80d31cbaed33
relation.isAuthorOfPublication.latestForDiscovery1aef4b60-4197-436b-84ab-80d31cbaed33

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