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The pharmacological effect of hemin in inflammatory-related diseases: protocol for a systematic review

2023-11Journal article Open access
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dc.contributor.authorEstarreja, João
dc.contributor.authorCaldeira, Gonçalo
dc.contributor.authorSilva, Inês
dc.contributor.authorMendes, Priscila
dc.contributor.authorMateus, Vanessa
dc.date.accessioned2023-12-08T12:40:39Z
dc.date.available2023-12-08T12:40:39Z
dc.date.issued2023-11
dc.description.abstractBackground: Hemin is a commonly used drug in the treatment of acute attacks of porphyria, due to its capability of restoring normal levels of hemoproteins and respiratory pigments. In addition, this drug has demonstrated the capacity to induce the heme oxygenase (HO) enzyme. At the moment, there are 3 known HO isoenzymes in mammals: HO-1, HO-2, and HO-3. The first of these shows cytoprotective, antioxidant, and anti-inflammatory effects. Currently, medicines used in inflammatory disorders have increased toxicity, especially over longer time frames, which highlights the need to investigate new, safer options. Indeed, the current nonclinical evidence demonstrates the potential that hemin has a significant anti-inflammatory effect in several animal models of inflammation-related diseases, such as experimental colitis, without significant side effects. However, the underlying mechanism(s) are still not fully understood. In addition, past nonclinical studies have applied different therapeutic regimens, making it relatively difficult to understand which is optimal. According to the literature, there is a lack of review articles discussing this topic, highlighting the need for a summary and analysis of the available preclinical evidence to elucidate the abovementioned issues. Therefore, a qualitative synthesis of the current evidence is essential for the research and medical communities. Objective: This systematic review aims to summarize and analyze currently available nonclinical data to ascertain the potential anti-inflammatory effect of hemin in animal models. Methods: Throughout the development of this protocol, we followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) protocol. The comprehensive search strategy will be carried out in MEDLINE (PubMed), Web of Science, and Scopus without any filters associated with publication date. Only in vivo, nonclinical studies that evaluated the potential anti-inflammatory effect of hemin will be included. The evaluated outcomes will be the observed clinical signs, inflammatory and other biochemical markers, and macroscopic and microscopic evaluations. To analyze the potential risk of bias, we will use the risk of bias tool developed by the Systematic Review Centre for Laboratory Animal Experimentation (SYRCLE). Results: Currently, it is not possible to disclose any results since the project is still in the initial steps. More specifically, we are currently engaged in the identification of eligible articles through the application of the inclusion and exclusion criteria. The work was initiated in April 2023, and it is expected to be finished at the end of 2023. Conclusions: Concerning the major gap in the literature regarding the underlying mechanism(s) and treatment-related properties, this systematic review will be essential to clearly summarize and critically analyze the nonclinical data available, promoting a clearer vision of the potential anti-inflammatory effect of hemin.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationEstarreja J, Caldeira G, Silva I, Mendes P, Mateus V. The pharmacological effect of hemin in inflammatory-related diseases: protocol for a systematic review. JMIR Res Protoc. 2023;12:e48368.pt_PT
dc.identifier.doi10.2196/48368pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/16652
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherJMIR Publicationspt_PT
dc.relation.publisherversionhttps://www.researchprotocols.org/2023/1/e48368pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectAnimal modelspt_PT
dc.subjectHeminpt_PT
dc.subjectIn vivopt_PT
dc.subjectInflammationpt_PT
dc.subjectNonclinical studiespt_PT
dc.subjectInflammatory-related diseasespt_PT
dc.subjectPharmacologypt_PT
dc.titleThe pharmacological effect of hemin in inflammatory-related diseases: protocol for a systematic reviewpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.startPagee48368pt_PT
oaire.citation.titleJMIR Research Protocolspt_PT
oaire.citation.volume12pt_PT
person.familyNameEstarreja
person.familyNameda Silva
person.familyNameRodrigues Gomes Mendes
person.familyNamePinho Mateus
person.givenNameJoão
person.givenNameInês Filipa Janeiro da Silva
person.givenNamePriscila
person.givenNameVanessa Alexandra
person.identifier.ciencia-idEB19-EDA2-704B
person.identifier.ciencia-idC010-323F-3266
person.identifier.ciencia-id6A16-5C18-F10B
person.identifier.ciencia-id5A12-571D-AD6A
person.identifier.orcid0000-0002-8283-3174
person.identifier.orcid0000-0001-7049-2512
person.identifier.orcid0000-0002-0013-3140
person.identifier.orcid0000-0002-3204-3772
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationd16a20d0-ac73-4989-b83d-abeab53139f7
relation.isAuthorOfPublication995e1831-ff5b-49e7-a6e3-8bc692212204
relation.isAuthorOfPublicationb02faa18-658e-4edc-b846-7c0b3646414c
relation.isAuthorOfPublication406041a5-682c-4f94-a4e2-ddbfc541313c
relation.isAuthorOfPublication.latestForDiscoveryd16a20d0-ac73-4989-b83d-abeab53139f7

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