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Influence of serum levels of vitamins A, D, and E as well as vitamin D receptor polymorphisms on micronucleus frequencies and other biomarkers of genotoxicity in workers exposed to formaldehyde

2015Journal article Restricted access
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dc.contributor.authorLadeira, Carina
dc.contributor.authorPádua, Mário
dc.contributor.authorVeiga, Luísa
dc.contributor.authorViegas, Susana
dc.contributor.authorCarolino, Elisabete
dc.contributor.authorGomes, Manuel C
dc.contributor.authorBrito, Miguel
dc.date.accessioned2016-06-29T15:05:06Z
dc.date.available2016-06-29T15:05:06Z
dc.date.issued2015
dc.description.abstractBackground/Aim: Formaldehyde is classified as carcinogenic to humans, making it a major concern, particularly in occupational settings. Fat-soluble vitamins, such as vitamins A, D, and E, are documented as antigenotoxic and antimutagenic and also correlate with the cell antioxidant potential. This study investigates the influence of these vitamins on genotoxicity biomarkers of formaldehyde-exposed hospital workers. Methods: The target population were hospital workers exposed to formaldehyde (n = 55). Controls were nonexposed individuals (n = 80). The most used genotoxicity biomarkers were the cytokinesis-block micronucleus assay for lymphocytes and the micronucleus test for exfoliated buccal cells. Vitamins A and E were determined by high-performance liquid chromatography with a diode array detector (HPLC-DAD) and vitamin D receptor (VDR) polymorphisms by real-time PCR. Results: Significant correlations were found between genotoxicity biomarkers and between vitamins A and E in controls. Multiple regression showed that vitamin A was significantly associated with a higher mean of nucleoplasmic bridges (p < 0.001), and vitamin E was significantly associated with a decreased frequency of nuclear buds (p = 0.045) in the exposed group. No effect of vitamin D was observed. The VDRBsmI TT genotype carriers presented higher means of all the genotoxicity biomarkers; however, we found no significant associations. Conclusions: The study suggests that vitamin levels may modulate direct signs of genotoxicity.pt_PT
dc.identifier.citationLadeira C, Pádua M, Veiga L, Viegas S, Carolino E, Brito M. Influence of serum levels of vitamins A, D, and E as well as vitamin D receptor polymorphisms on micronucleus frequencies and other biomarkers of genotoxicity in workers exposed to formaldehyde. J Nutrigenet Nutrigenomics. 2015;8(4-6):205-14. Epub 2016 Mar 18.pt_PT
dc.identifier.doi10.1159/000444486pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/6258
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherKargerpt_PT
dc.relation.publisherversionhttp://www.karger.com/Article/Abstract/444486pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectOccupational exposurept_PT
dc.subjectGenotoxicitypt_PT
dc.subjectFormaldehydept_PT
dc.subjectPolymorphismspt_PT
dc.subjectSerum levelspt_PT
dc.subjectVitaminspt_PT
dc.subjectBiomarkerpt_PT
dc.subjectHospitalpt_PT
dc.titleInfluence of serum levels of vitamins A, D, and E as well as vitamin D receptor polymorphisms on micronucleus frequencies and other biomarkers of genotoxicity in workers exposed to formaldehydept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage214pt_PT
oaire.citation.issue4-6pt_PT
oaire.citation.startPage205pt_PT
oaire.citation.titleJournal of Nutrigenetics and Nutrigenomicspt_PT
oaire.citation.volume8pt_PT
person.familyNameLadeira
person.familyNameVeiga
person.familyNameViegas
person.familyNameCarolino
person.familyNameBrito
person.givenNameCarina
person.givenNameLuisa
person.givenNameSusana
person.givenNameElisabete
person.givenNameMiguel
person.identifier144237
person.identifier248817
person.identifier.ciencia-id801C-1BBA-1D9E
person.identifier.ciencia-id9413-918D-DB0E
person.identifier.ciencia-idA919-7318-63DC
person.identifier.ciencia-id1216-EFA3-1E0F
person.identifier.ciencia-id231F-F341-7E93
person.identifier.orcid0000-0001-5588-0074
person.identifier.orcid0000-0003-1153-8343
person.identifier.orcid0000-0003-1015-8760
person.identifier.orcid0000-0003-4165-7052
person.identifier.orcid0000-0001-6394-658X
person.identifier.ridJ-2572-2012
person.identifier.ridL-2730-2013
person.identifier.ridI-4053-2012
person.identifier.ridF-1012-2015
person.identifier.ridA-7970-2016
person.identifier.scopus-author-id36463788000
person.identifier.scopus-author-id8318978600
person.identifier.scopus-author-id35270591500
person.identifier.scopus-author-id25821697000
person.identifier.scopus-author-id35224551000
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
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