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Effects of Quercetin in transcriptional and post-transcriptional regulation of fetal hemoglobin

2023-06Conference object Open access
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dc.contributor.authorCanteiro, Beatriz
dc.contributor.authorMendes, Maria
dc.contributor.authorJacques, Filipa
dc.contributor.authorDelgadinho, Mariana
dc.contributor.authorOliveira, Ketlyn
dc.contributor.authorGinete, Catarina
dc.contributor.authorGomes, Mário
dc.contributor.authorRibeiro, Edna
dc.contributor.authorBrito, Miguel
dc.contributor.authorGomes, Anita Q.
dc.date.accessioned2024-01-15T14:53:37Z
dc.date.available2024-01-15T14:53:37Z
dc.date.issued2023-06
dc.descriptionThis project was supported by Instituto Politécnico de Lisboa under the grant IDI&CAIPL/2022/miRCa/ESTeSL and partially supported by FCT/MCTES (UIDB/05608/2020 and UIDP/05608/2020). The authors are grateful to Fernando Nunes for kindly providing the Carica papaya leaves.pt_PT
dc.description.abstractHemoglobinopathies are a group of inherited blood disorders that primarily affect red blood cells. The most common type is known as sickle cell anemia (SCA). It is characterized by mutations in the HBB gene, which encodes the β-subunit of human hemoglobin, giving rise to hemoglobin S (HbS). When deoxygenated, HbS polymerizes in the red blood cell, giving it a sickle shape and making it rigid and fragile. Fetal hemoglobin (HbF) is the major genetic modulator of the hematologic and clinical features of sickle cell disease, an effect mediated by its exclusion from the sickle hemoglobin polymer. Fetal hemoglobin genes are genetically regulated, and the level of HbF and its distribution among sickle erythrocytes is highly variable. Currently, therapies that induce HbF are promising, such as hydroxyurea (HU). However, due to high costs for underdeveloped countries and the adverse side effects, it is important to test alternative products and develop new compounds, such as Quercetin, a natural flavonoid present in plants that has antioxidant and anti-inflammatory properties.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationCanteiro B, Delgadinho M, Oliveira K, Ginete C, Gomes M, Ribeiro E, Brito M, Gomes AQ, et al. Effects of Quercetin in transcriptional and post-transcriptional regulation of fetal hemoglobin. In: 7th ENBENG IEEE Portuguese Meeting in Bioengineering, Faculty of Engineeering of University of Porto (Portugal), June 22-23, 2023.pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/16887
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relationIDI&CA-IPL/2022/miRCa/ESTeSLpt_PT
dc.relation.publisherversionhttps://ieeexplore.ieee.org/xpl/conhome/10175314/proceedingpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectSickle cell diseasept_PT
dc.subjectReactivation of fetal hemoglobinpt_PT
dc.subjectQuercetinpt_PT
dc.subjectFlavonoidpt_PT
dc.subjectHydroxyureapt_PT
dc.subjectHbF regulatory/silencing genespt_PT
dc.subjectIDI&CA-IPL/2022/miRCa/ESTeSLpt_PT
dc.subjectFCT_UIDB/05608/2020pt_PT
dc.subjectFCT_UIDP/05608/2020pt_PT
dc.titleEffects of Quercetin in transcriptional and post-transcriptional regulation of fetal hemoglobinpt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.citation.conferencePlacePortopt_PT
person.familyNameNeves Delgadinho
person.familyNameHonrado Ginete
person.familyNameRibeiro
person.familyNameBrito
person.familyNameGomes
person.givenNameMariana Isabel
person.givenNameAna Catarina
person.givenNameEdna
person.givenNameMiguel
person.givenNameAnita
person.identifierCAJ-5082-2022
person.identifier.ciencia-id231E-02E3-D9A9
person.identifier.ciencia-id8715-F62E-1E0F
person.identifier.ciencia-idC414-CDF2-D35A
person.identifier.ciencia-id231F-F341-7E93
person.identifier.ciencia-id4B10-E015-52B7
person.identifier.orcid0000-0003-0586-9154
person.identifier.orcid0000-0002-2334-782X
person.identifier.orcid0000-0003-1316-7750
person.identifier.orcid0000-0001-6394-658X
person.identifier.orcid0000-0002-3348-0448
person.identifier.ridA-7970-2016
person.identifier.ridC-3580-2014
person.identifier.scopus-author-id35224551000
person.identifier.scopus-author-id7202386033
rcaap.rightsopenAccesspt_PT
rcaap.typeconferenceObjectpt_PT
relation.isAuthorOfPublicationca55aab6-9a58-4f79-ab79-20513414099f
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