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TNBS-induced colitis in rodents: preliminary results of a chronic model

2019-07Conference object Open access
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dc.contributor.authorSilva, Inês
dc.contributor.authorMateus, Vanessa
dc.contributor.authorPinto, Rui
dc.date.accessioned2020-12-28T21:15:53Z
dc.date.available2020-12-28T21:15:53Z
dc.date.issued2019-07
dc.description.abstractBackground: Inflammatory bowel disease (IBD) is a gastrointestinal disorder characterized by chronic inflammation of the intestinal epithelium. The symptoms of IBD depend on the intestinal affected segment and usually include diarrhea often with blood, colic abdominal pain, and fecal urgency. Beyond these, other unspecific symptoms may occur like fever, loss of appetite and weight, fatigue, and primary amenorrhea. Nowadays, used therapy in IBD consists of salicylates, corticosteroids, immunosuppressants, and biological therapy. These drugs aim to induce and/or maintain the patient in remission and ameliorate the disease’s secondary effects, rather than modifying or reversing the underlying pathogenic mechanism. Aim: Development of an animal model of trinitrobenzene sulfonic acid (TNBS)-induced chronic colitis in order to evaluate the influence of new drugs in the IBD.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSilva IJ, Mateus V, Pinto R. TNBS-induced colitis in rodents: preliminary results of a chronic model. In: 11th iMed.ULisboa Postgraduate Students Meeting & 4th i3DU Meeting, Faculdade de Farmácia da Universidade de Lisboa (Portugal), July 15, 2019.pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/12530
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relation.publisherversionhttps://6d0a3f93-490a-4aaa-8c5a-70276e6c4de8.filesusr.com/ugd/8df66d_619e159e49f34f4a9f5e674c5c960889.pdfpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectInflammatory bowel diseasept_PT
dc.subjectChronic inflammationpt_PT
dc.subjectColitispt_PT
dc.subjectTNBSpt_PT
dc.subjectTrinitrobenzene sulfonic acidpt_PT
dc.titleTNBS-induced colitis in rodents: preliminary results of a chronic modelpt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.citation.conferencePlaceLisboapt_PT
person.familyNameda Silva
person.familyNamePinho Mateus
person.givenNameInês Filipa Janeiro da Silva
person.givenNameVanessa Alexandra
person.identifier.ciencia-idC010-323F-3266
person.identifier.ciencia-id5A12-571D-AD6A
person.identifier.orcid0000-0001-7049-2512
person.identifier.orcid0000-0002-3204-3772
rcaap.rightsopenAccesspt_PT
rcaap.typeconferenceObjectpt_PT
relation.isAuthorOfPublication995e1831-ff5b-49e7-a6e3-8bc692212204
relation.isAuthorOfPublication406041a5-682c-4f94-a4e2-ddbfc541313c
relation.isAuthorOfPublication.latestForDiscovery995e1831-ff5b-49e7-a6e3-8bc692212204

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