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Is mobile phone radiation genotoxic? An analysis of micronucleus frequency in exfoliated buccal cells

2017-08Journal article Restricted access
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dc.contributor.authorOliveira, Flávia Mendes de
dc.contributor.authorCarmona, Marta
dc.contributor.authorLadeira, Carina
dc.date.accessioned2017-08-16T16:16:40Z
dc.date.available2017-08-16T16:16:40Z
dc.date.issued2017-08
dc.description.abstractElectromagnetic fields (EMF) are classified as “possibly carcinogenic” by the International Agency for Research on Cancer (IARC). Some publications have reported associations between EMF exposure and DNA damage, but many other studies contradict such findings. Cytomorphological changes, such as micronuclei (MN), indicative of genomic damage, are biomarkers of genotoxicity. To test whether mobile phone-associated EMF exposure affects the MN frequency in exfoliated buccal cells, we obtained cells smears from the left and right inner cheeks of healthy mobile phone users, aged 18–30 (n = 86), who also completed a characterization survey. MN frequencies were tested for potential confounding factors and for duration of phone use and preferential side of mobile phone use. No relationship was observed between MN frequency and duration of mobile phone use in daily calls. Cells ipsilateral to mobile phone use did not present a statistically significantly higher MN frequency, compared to cells contralateral to exposure. A highly statistically significant (p < 0.0001) increase in MN frequency was found in subjects reporting regular exposure to genotoxic agents. Therefore, our results suggest that mobile phone-associated EMF does not to induce MN formation in buccal cells at the observed exposure levels.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationOliveira FM, Carmona AM, Ladeira C. Is mobile phone radiation genotoxic? An analysis of micronucleus frequency in exfoliated buccal cells. Mutat Res Gen Tox En. 2017;822:41-6.pt_PT
dc.identifier.doi10.1016/j.mrgentox.2017.08.001pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/7323
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relation.publisherversionhttp://www.sciencedirect.com/science/article/pii/S1383571817300542pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectPublic healthpt_PT
dc.subjectElectromagnetic fieldspt_PT
dc.subjectMobile phonept_PT
dc.subjectGenotoxicitypt_PT
dc.subjectMicronucleipt_PT
dc.subjectExfoliated buccal cellspt_PT
dc.subjectFeulgen stainpt_PT
dc.titleIs mobile phone radiation genotoxic? An analysis of micronucleus frequency in exfoliated buccal cellspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage46pt_PT
oaire.citation.startPage41pt_PT
oaire.citation.titleMutation Research - Genetic Toxicology and Environmental Mutagenesispt_PT
oaire.citation.volume822pt_PT
person.familyNameLadeira
person.givenNameCarina
person.identifier144237
person.identifier.ciencia-id801C-1BBA-1D9E
person.identifier.orcid0000-0001-5588-0074
person.identifier.ridJ-2572-2012
person.identifier.scopus-author-id36463788000
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication1aef4b60-4197-436b-84ab-80d31cbaed33
relation.isAuthorOfPublication.latestForDiscovery1aef4b60-4197-436b-84ab-80d31cbaed33

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