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PET/CT in the evaluation of hypoxia for radiotherapy planning in head and neck tumors: systematic literature review

2021-06Journal article Open access
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dc.contributor.authorLopes, Susana Isabel
dc.contributor.authorFerreira, Sara
dc.contributor.authorCaetano, Marco
dc.date.accessioned2021-03-27T18:15:33Z
dc.date.available2021-03-27T18:15:33Z
dc.date.issued2021-06
dc.description.abstractIntroduction: PET/CT combines the molecular with the anatomical level which, with the administration of a hypoxia-sensitive radiopharmaceutical, allows the evaluation of tissue oxygenation. Materials and Methods: The work consists of a systematic literature review, including electronic addresses, books, and articles dating from July 1997 to December 2019. The aim of this work is to identify the best-suited PET radiopharmaceuticals for the detection of cell hypoxia and recognize the benefits for treatment planning with IMRT/VMAT techniques. Results: Hypoxia affects the likelihood of cure of head and neck tumors, thereby reducing the success rate. Radiopharmaceuticals such as 18F-FMISO, 18F-FETNIM, and 18F-HX4 allow the delineation of hypoxic subvolumes within the target volume to optimize IMRT/VMAT treatment. Discussion: The identification of hypoxia areas with PET/CT imaging and subsequent treatment with IMRT/VMAT allows a possible radiation dose escalation in radioresistant subvolumes. Conclusion: There is a decrease in relapses and an increased likelihood of disease-free survival.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationLopes SI, Ferreira S, Caetano M. PET/CT in the evaluation of hypoxia for radiotherapy planning in head and neck tumors: systematic literature review. J Nucl Med Technol. 2021;49(2):107-13.pt_PT
dc.identifier.doi10.2967/jnmt.120.249540pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/13161
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSNMMIpt_PT
dc.relation.publisherversionhttps://tech.snmjournals.org/content/early/2020/12/23/jnmt.120.249540pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectMolecular imagingpt_PT
dc.subjectOncology, Head and neckpt_PT
dc.subjectPET/CTpt_PT
dc.subjectRadiopharmaceuticalspt_PT
dc.subjectHead and neck tumourspt_PT
dc.subjectHypoxic cellspt_PT
dc.subjectRadiotherapypt_PT
dc.subjectTreatment planningpt_PT
dc.titlePET/CT in the evaluation of hypoxia for radiotherapy planning in head and neck tumors: systematic literature reviewpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage113pt_PT
oaire.citation.issue2pt_PT
oaire.citation.startPagejnmt.120.249540pt_PT
oaire.citation.startPage107pt_PT
oaire.citation.titleJournal of Nuclear Medicine Technologypt_PT
oaire.citation.volume49pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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