| Name: | Description: | Size: | Format: | |
|---|---|---|---|---|
| 432.62 KB | Adobe PDF |
Advisor(s)
Abstract(s)
Introduction: PET/CT combines the molecular with the anatomical level which, with the administration of a hypoxia-sensitive radiopharmaceutical, allows the evaluation of tissue oxygenation. Materials and Methods: The work consists of a systematic literature review, including electronic addresses, books, and articles dating from July 1997 to December 2019. The aim of this work is to identify the best-suited PET radiopharmaceuticals for the detection of cell hypoxia and recognize the benefits for treatment planning with IMRT/VMAT techniques. Results: Hypoxia affects the likelihood of cure of head and neck tumors, thereby reducing the success rate. Radiopharmaceuticals such as 18F-FMISO, 18F-FETNIM, and 18F-HX4 allow the delineation of hypoxic subvolumes within the target volume to optimize IMRT/VMAT treatment. Discussion: The identification of hypoxia areas with PET/CT imaging and subsequent treatment with IMRT/VMAT allows a possible radiation dose escalation in radioresistant subvolumes. Conclusion: There is a decrease in relapses and an increased likelihood of disease-free survival.
Description
Keywords
Molecular imaging Oncology, Head and neck PET/CT Radiopharmaceuticals Head and neck tumours Hypoxic cells Radiotherapy Treatment planning
Citation
Lopes SI, Ferreira S, Caetano M. PET/CT in the evaluation of hypoxia for radiotherapy planning in head and neck tumors: systematic literature review. J Nucl Med Technol. 2021;49(2):107-13.
Publisher
SNMMI