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Identification of a 0.4 Kb deletion region in 10q26 associated with endometrial carcinoma

2010-02Journal article Open access
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dc.contributor.authorAlves, Margarida
dc.contributor.authorCarreira, Isabel
dc.contributor.authorLiberato, Paulo
dc.contributor.authorRamos, Sância
dc.contributor.authorMafra, Manuela
dc.contributor.authorInverno, Alexandra S.
dc.contributor.authorMaia, Ana T.
dc.contributor.authorMartins, Ana Paula
dc.contributor.authorBrito, Miguel
dc.contributor.authorMonteiro, Carolino
dc.date.accessioned2014-01-03T22:35:50Z
dc.date.available2014-01-03T22:35:50Z
dc.date.issued2010-02
dc.description.abstractWe have identified an allelic deletion common region in the q26 region of chromosome 10 in endometrial carcinomas, which has been reported previously as a potential target of genetic alterations related to this neoplasia. An allelotyping analysis of 19 pairs of tumoral and non-tumoral samples was accomplished using seven microsatellite polymorphic markers mapping in the 10q26 chromosomal region. Loss of heterozygosity for one or more loci was detected in 29% of the endometrial carcinoma samples. The observed pattern of loss enabled the identification of a 3.5 Mb common deleted region located between the D10S587 and D10S186 markers. An additional result from an endometrial sample with evidence of a RER phenotype may suggest a more centromeric region of loss within the above-mentioned interval. This 401.84 Kb interval flanked by the D10S587 and D10S216 markers may be a plausible location for a putative suppressor gene involved in early stage endometrial carcinogenesis.por
dc.identifier.citationAlves M, Carreira I, Liberato P, Ramos S, Mafra M, Brito M, et al. Identification of a 0.4 Kb deletion region in 10q26 associated with endometrial carcinoma. Oncol Rep. 2010;23(2):519-22.por
dc.identifier.issn1791-2431
dc.identifier.urihttp://hdl.handle.net/10400.21/3070
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherSpandidos Publicationspor
dc.relation.publisherversionhttp://www.spandidos-publications.com/or/23/2/519por
dc.subjectCarcinomapor
dc.subjectChromosome deletionpor
dc.subjectChromosome mappingpor
dc.subjectDNA mutational analysispor
dc.subjectDNA replicationpor
dc.subjectEndometrial neoplasmspor
dc.subjectGenetic linkagepor
dc.subjectLoss of heterozygositypor
dc.subjectMatched-Pair analysispor
dc.subjectMicrosatellite instabilitypor
dc.titleIdentification of a 0.4 Kb deletion region in 10q26 associated with endometrial carcinomapor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage522por
oaire.citation.startPage519por
oaire.citation.titleOncology Reportspor
oaire.citation.volume23por
person.familyNameBrito
person.givenNameMiguel
person.identifier.ciencia-id231F-F341-7E93
person.identifier.orcid0000-0001-6394-658X
person.identifier.ridA-7970-2016
person.identifier.scopus-author-id35224551000
rcaap.rightsopenAccesspor
rcaap.typearticlepor
relation.isAuthorOfPublication4252d8e0-800c-4d67-8b13-0b711d860669
relation.isAuthorOfPublication.latestForDiscovery4252d8e0-800c-4d67-8b13-0b711d860669

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