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Orientador(es)
Resumo(s)
We have identified an allelic deletion common region in the q26 region of chromosome 10 in endometrial carcinomas, which has been reported previously as a potential target of genetic alterations related to this neoplasia. An allelotyping analysis of 19 pairs of tumoral and non-tumoral samples was accomplished using seven microsatellite polymorphic markers mapping in the 10q26 chromosomal region. Loss of heterozygosity for one or more loci was detected in 29% of the endometrial carcinoma samples. The observed pattern of loss enabled the identification of a 3.5 Mb common deleted region located between the D10S587 and D10S186 markers. An additional result from an endometrial sample with evidence of a RER phenotype may suggest a more centromeric region of loss within the above-mentioned interval. This 401.84 Kb interval flanked by the D10S587 and D10S216 markers may be a plausible location for a putative suppressor gene involved in early stage endometrial carcinogenesis.
Descrição
Palavras-chave
Carcinoma Chromosome deletion Chromosome mapping DNA mutational analysis DNA replication Endometrial neoplasms Genetic linkage Loss of heterozygosity Matched-Pair analysis Microsatellite instability
Contexto Educativo
Citação
Alves M, Carreira I, Liberato P, Ramos S, Mafra M, Brito M, et al. Identification of a 0.4 Kb deletion region in 10q26 associated with endometrial carcinoma. Oncol Rep. 2010;23(2):519-22.