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Exposure and genotoxicity assessment methodologies: the case of formaldehyde occupational exposure

2013-07Journal article Restricted access
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dc.contributor.authorViegas, Susana
dc.contributor.authorLadeira, Carina
dc.contributor.authorGomes, Mário
dc.contributor.authorNunes, Carla
dc.contributor.authorBrito, Miguel
dc.contributor.authorPrista, João
dc.date.accessioned2013-11-08T14:17:21Z
dc.date.available2013-11-08T14:17:21Z
dc.date.issued2013-07
dc.description.abstractFormaldehyde (FA) ranks 25th in the overall U.S. chemical production, with more than 5 million tons produced each year. Given its economic importance and widespread use, many people are exposed to FA occupationally. Recently, based on the correlation with nasopharyngeal cancer in humans, the International Agency for Research on Cancer (IARC) confirmed the classification of FA as a Group I substance. Considering the epidemiological evidence of a potential association with leukemia, the IARC has concluded that FA can cause this lymphoproliferative disorder. Our group has developed a method to assess the exposure and genotoxicity effects of FA in two different occupational settings, namely FAbased resins production and pathology and anatomy laboratories. For exposure assessment we applied simultaneously two different techniques of air monitoring: NIOSH Method 2541 and Photo Ionization Detection Equipment with simultaneously video recording. Genotoxicity effects were measured by cytokinesis-blocked micronucleus assay in peripheral blood lymphocytes and by micronucleus test in exfoliated oral cavity epithelial cells, both considered target cells. The two exposure assessment techniques show that in the two occupational settings peak exposures are still occurring. There was a statistical significant increase in the micronucleus mean of epithelial cells and peripheral lymphocytes of exposed individuals compared with controls. In conclusion, the exposure and genotoxicity effects assessment methodologies developed by us allowed to determine that these two occupational settings promote exposure to high peak FA concentrations and an increase in the micronucleus mean of exposed workers. Moreover, the developed techniques showed promising results and could be used to confirm and extend the results obtained by the analytical techniques currently available.por
dc.identifier.citationViegas S, Ladeira C, Gomes M, Nunes C, Brito M, Prista J. Exposure and genotoxicity assessment methodologies: the case of formaldehyde occupational exposure. Curr Anal Chem. 2013;9(3):476-84.por
dc.identifier.issn1573-4110
dc.identifier.urihttp://hdl.handle.net/10400.21/2888
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherBentham Sciencepor
dc.relation.publisherversionhttp://www.ingentaconnect.com/content/ben/cac/2013/00000009/00000003/art00017por
dc.subjectOccupational exposurepor
dc.subjectChemistrypor
dc.subjectRisk assessmentpor
dc.subjectLymphohematopoietic malignanciespor
dc.subjectPeripheral lymphocytespor
dc.subjectInhalation exposurepor
dc.subjectMucosa cellspor
dc.subjectDNA damagepor
dc.subjectMortalitypor
dc.subjectLeukemiapor
dc.titleExposure and genotoxicity assessment methodologies: the case of formaldehyde occupational exposurepor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage484por
oaire.citation.startPage476por
oaire.citation.titleCurrent Analytical Chemistrypor
oaire.citation.volume9por
person.familyNameViegas
person.familyNameLadeira
person.familyNameBrito
person.givenNameSusana
person.givenNameCarina
person.givenNameMiguel
person.identifier248817
person.identifier144237
person.identifier.ciencia-idA919-7318-63DC
person.identifier.ciencia-id801C-1BBA-1D9E
person.identifier.ciencia-id231F-F341-7E93
person.identifier.orcid0000-0003-1015-8760
person.identifier.orcid0000-0001-5588-0074
person.identifier.orcid0000-0001-6394-658X
person.identifier.ridI-4053-2012
person.identifier.ridJ-2572-2012
person.identifier.ridA-7970-2016
person.identifier.scopus-author-id35270591500
person.identifier.scopus-author-id36463788000
person.identifier.scopus-author-id35224551000
rcaap.rightsembargoedAccesspor
rcaap.typearticlepor
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relation.isAuthorOfPublication1aef4b60-4197-436b-84ab-80d31cbaed33
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relation.isAuthorOfPublication.latestForDiscovery1aef4b60-4197-436b-84ab-80d31cbaed33

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