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Epigallocatechin-3-gallate (EGCG): an alternative to extenuate occupational risk factors outcomes? An interventional study

2023Book part Open access
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dc.contributor.authorLadeira, Carina
dc.contributor.authorPádua, Mário
dc.contributor.authorRibeiro, Edna
dc.date.accessioned2022-12-14T18:04:35Z
dc.date.available2024-12-14T01:30:21Z
dc.date.issued2023
dc.descriptionFCT_UIDB/05608/2020. FCT_UIDP/05608/2020.pt_PT
dc.description.abstractIntroduction: Occupational risk factors are major players in the increased risk of cardiovascular diseases and cancer. Studies support a protective role of Epigallocatechin-3-gallate (EGCG) in disease onset, with associated antioxidant properties and reactive oxygen species production. We aimed to evaluate the in vivo effects of EGCG intake on cardiovascular risk factors, DNA damage, and oxidative DNA damage. Methods: Voluntaries were enrolled in this interventional study with the safeguard of all ethical considerations. Peripheral blood was collected at the beginning and after 90 days of 225 mg EGCG ingestion per day. Lipid profile and liver function parameters were assessed using colorimetric methods. Vitamins A and E in serum were quantified by HPLC–DAD. DNA damage and oxidative DNA damage were assessed through comet assay. Results: Vitamin A, as well as the lipid profile and liver function parameters, were not affected by EGCG intake, whereas serum levels of vitamin E, DNA damage, and DNA oxidative damage increased after EGCG consumption. Discussion/Conclusions: EGCG induces low-level oxidative stress which may trigger protective antioxidant systems associated with vitamin E. Further research is crucial to understand the extent of EGCG effects and its potential as an alternative to extenuate occupational risk factors outcomes.pt_PT
dc.description.sponsorshipH&TRC authors gratefully acknowledge the FCT/MCTES national support and the financial and institutional support of the Health & Technology Research Center, ESTeSL- Escola Superior de Tecnologia da Saúde, Instituto Politécnico de Lisboa.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationLadeira C, Pádua M, Ribeiro E. Epigallocatechin-3-gallate (EGCG): an alternative to extenuate occupational risk factors outcomes? An interventional study. In: Arezes PM, Baptista JS, Melo RB, Castelo Branco J, Carneiro P, Colim A, et al, editors. Occupational and environmental safety and health IV: studies in systems, decision and control. Vol. 449. Cham: Springer; 2023. p. 411-24.pt_PT
dc.identifier.doi10.1007/978-3-031-12547-8_34pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/15151
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringerpt_PT
dc.relation.publisherversionhttps://link.springer.com/chapter/10.1007/978-3-031-12547-8_34pt_PT
dc.subjectOccupational risk factorspt_PT
dc.subjectEpigallocatechin-3-gallate (EGCG)pt_PT
dc.subjectHematologic parameterspt_PT
dc.subjectOxidative DNA damagept_PT
dc.subjectAntioxidant defence systemspt_PT
dc.subjectFCT_UIDB/05608/2020pt_PT
dc.subjectFCT_UIDP/05608/2020pt_PT
dc.titleEpigallocatechin-3-gallate (EGCG): an alternative to extenuate occupational risk factors outcomes? An interventional studypt_PT
dc.typebook part
dspace.entity.typePublication
oaire.citation.endPage424pt_PT
oaire.citation.startPage411pt_PT
oaire.citation.volume449pt_PT
person.familyNameLadeira
person.familyNameRibeiro
person.givenNameCarina
person.givenNameEdna
person.identifier144237
person.identifier.ciencia-id801C-1BBA-1D9E
person.identifier.ciencia-idC414-CDF2-D35A
person.identifier.orcid0000-0001-5588-0074
person.identifier.orcid0000-0003-1316-7750
person.identifier.ridJ-2572-2012
person.identifier.scopus-author-id36463788000
rcaap.rightsopenAccesspt_PT
rcaap.typebookPartpt_PT
relation.isAuthorOfPublication1aef4b60-4197-436b-84ab-80d31cbaed33
relation.isAuthorOfPublicationa571bf34-bcda-49ca-b5cb-4cdecbb3d9c7
relation.isAuthorOfPublication.latestForDiscoverya571bf34-bcda-49ca-b5cb-4cdecbb3d9c7

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