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From thymus to periphery: molecular basis of effector γδ‐T cell differentiation

2020-11Journal article Open access
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dc.contributor.authorFiala, Gina J.
dc.contributor.authorGomes, Anita Q.
dc.contributor.authorSilva‐Santos, Bruno
dc.date.accessioned2020-12-04T21:50:37Z
dc.date.available2020-12-04T21:50:37Z
dc.date.issued2020-11
dc.descriptionH2020 European Research Council. Grant Number: CoG_676401. European Commission Marie Sklodowska‐Curie Individual Fellowship. Grant Number: 752932.pt_PT
dc.description.abstractThe contributions of γδ T cells to immune (patho)physiology in many pre-clinical mouse models have been associated with their rapid and abundant provision of two critical cytokines, interferon-γ (IFN-γ) and interleukin-17A (IL-17). These are typically produced by distinct effector γδ T cell subsets that can be segregated on the basis of surface expression levels of receptors such as CD27, CD44, or CD45RB, among others. Unlike conventional T cells that egress the thymus as naïve lymphocytes awaiting further differentiation upon activation, a large fraction of murine γδ T cells commits to either IFN-γ or IL-17 expression during thymic development. However, extrathymic signals can both regulate pre-programmed γδ T cells; and induce peripheral differentiation of naïve γδ T cells into effectors. Here we review the key cellular events of "developmental pre-programming" in the mouse thymus; and the molecular basis for effector function maintenance vs plasticity in the periphery. We highlight some of our contributions towards elucidating the role of T cell receptor, co-receptors (like CD27 and CD28) and cytokine signals (such as IL-1β and IL-23) in these processes, and the various levels of gene regulation involved, from the chromatin landscape to microRNA-based post-transcriptional control of γδ T cell functional plasticity.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationFiala GJ, Gomes AQ, Silva-Santos B. From thymus to periphery: molecular basis of effector γδ‐T cell differentiation. Immunol Rev. 2020;298(1):47-60.pt_PT
dc.identifier.doi10.1111/imr.12918pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/12413
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherWileypt_PT
dc.relationH2020 European Research Council. Grant Number: CoG_676401pt_PT
dc.relationEuropean Commission Marie Sklodowska‐Curie Individual Fellowship. Grant Number: 752932pt_PT
dc.relation.publisherversionhttps://onlinelibrary.wiley.com/doi/10.1111/imr.12918pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectEffector T cell differentiationpt_PT
dc.subjectGamma-delta T cellspt_PT
dc.subjectIL-17pt_PT
dc.subjectThymic T cell developmentpt_PT
dc.titleFrom thymus to periphery: molecular basis of effector γδ‐T cell differentiationpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage60pt_PT
oaire.citation.issue1pt_PT
oaire.citation.startPage47pt_PT
oaire.citation.titleImmunological Reviewspt_PT
oaire.citation.volume298pt_PT
person.familyNameGomes
person.givenNameAnita
person.identifier.ciencia-id4B10-E015-52B7
person.identifier.orcid0000-0002-3348-0448
person.identifier.ridC-3580-2014
person.identifier.scopus-author-id7202386033
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication2b5a3f0a-29c2-4ecd-a83f-50d0b99a4875
relation.isAuthorOfPublication.latestForDiscovery2b5a3f0a-29c2-4ecd-a83f-50d0b99a4875

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