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MOB: pivotal conserved proteins in cytokinesis, cell architecture and tissue homeostasis

2020-11Journal article Open access
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dc.contributor.authorDelgado, Inês L. S.
dc.contributor.authorCarmona, Bruno
dc.contributor.authorNolasco, Sofia
dc.contributor.authorSantos, Dulce
dc.contributor.authorLeitão, Alexandre
dc.contributor.authorSoares, Helena
dc.date.accessioned2020-12-06T18:23:14Z
dc.date.available2020-12-06T18:23:14Z
dc.date.issued2020-11
dc.descriptionUID/QUI/00100/2019. Project IPL/2019/MOONOFCILI/ESTeSLpt_PT
dc.description.abstractThe MOB family proteins are constituted by highly conserved eukaryote kinase signal adaptors that are often essential both for cell and organism survival. Historically, MOB family proteins have been described as kinase activators participating in Hippo and Mitotic Exit Network/ Septation Initiation Network (MEN/SIN) signaling pathways that have central roles in regulating cytokinesis, cell polarity, cell proliferation, and cell fate to control organ growth and regeneration. In metazoans, MOB proteins act as central signal adaptors of the core kinase module MST1/2, LATS1/2, and NDR1/2 kinases that phosphorylate the YAP/TAZ transcriptional co-activators, effectors of the Hippo signaling pathway. More recently, MOBs have been shown to also have non-kinase partners and to be involved in cilia biology, indicating that its activity and regulation is more diverse than expected. In this review, we explore the possible ancestral role of MEN/SIN pathways on the built-in nature of a more complex and functionally expanded Hippo pathway, by focusing on the most conserved components of these pathways, the MOB proteins. We discuss the current knowledge of MOBs-regulated signaling, with emphasis on its evolutionary history and role in morphogenesis, cytokinesis, and cell polarity from unicellular to multicellular organisms.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationDelgado IL, Carmona B, Nolasco S, Santos D, Leitão A, Soares H. MOB: pivotal conserved proteins in cytokinesis, cell architecture and tissue homeostasis. Biology (Basel). 2020;9(12):E413.pt_PT
dc.identifier.doi10.3390/biology9120413pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/12415
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationProject IPL/2019/MOONOFCILI/ESTeSLpt_PT
dc.relationCentro de Química Estrutural
dc.relation.publisherversionhttps://www.mdpi.com/2079-7737/9/12/413pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectMOBpt_PT
dc.subjectCell polaritypt_PT
dc.subjectCytokinesispt_PT
dc.subjectTissue homeostasispt_PT
dc.subjectProliferationpt_PT
dc.subjectMorphogenesispt_PT
dc.subjectHippopt_PT
dc.subjectMENpt_PT
dc.subjectUID/QUI/00100/2019pt_PT
dc.subjectIPL/2019/MOONOFCILI/ESTeSLpt_PT
dc.titleMOB: pivotal conserved proteins in cytokinesis, cell architecture and tissue homeostasispt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleCentro de Química Estrutural
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FQUI%2F00100%2F2019/PT
oaire.citation.issue12pt_PT
oaire.citation.startPageE413pt_PT
oaire.citation.titleBiologypt_PT
oaire.citation.volume9pt_PT
oaire.fundingStream6817 - DCRRNI ID
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isProjectOfPublicationc186ee3a-14ef-428f-82a2-4a3bd8efd756
relation.isProjectOfPublication.latestForDiscoveryc186ee3a-14ef-428f-82a2-4a3bd8efd756

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