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MicroRNA-146a controls IFN-g production and functional plasticity of murine gd T cells by targeting Nod1

2018-03Conference object Open access
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dc.contributor.authorSchmolka, Nina
dc.contributor.authorPapotto, Pedro H.
dc.contributor.authorRomero, Paula Vargas
dc.contributor.authorAmado, Tiago
dc.contributor.authorEnguita, Francisco J.
dc.contributor.authorAmorim, Ana
dc.contributor.authorGordon, Katrina E.
dc.contributor.authorBoldin, Mark
dc.contributor.authorSerre, Karine
dc.contributor.authorBuck, Amy H.
dc.contributor.authorGomes, Anita Quintal
dc.contributor.authorSilva-Santos, Bruno
dc.date.accessioned2019-05-16T15:58:27Z
dc.date.available2019-05-16T15:58:27Z
dc.date.issued2018-03
dc.description.abstractγδ T cells have emerged as key providers of the proinflammatory cytokines interleukin 17 (IL-17) and interferon-γ (IFN-γ) in various models of infection, inflammation, and autoimmunity. Our previous epigenetic and transcriptional analyses have shown that whereas CD27+ γδ T cells are committed to IFN-γ expression, the IL-17 producing CD27- subset has limited plasticity to co-express both cytokines under inflammatory conditions (Schmolka et al. Nat Immunol 2013). To further understand the molecular control of this plasticity we now investigated the potential role of microRNA (miRNA)-mediated post-transcriptional regulation.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSchmolka N, Papotto, PH, Paula VP, Amado T, Gomes AQ, Silva-Santos B, et al. MicroRNA-146a controls IFN-g production and functional plasticity of murine gd T cells by targeting Nod1. In: 12th World Immune Regulation Meeting, Bern (Switzerland), March 14-17, 2018.pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/10032
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectImmunologypt_PT
dc.subjectInflammatory cytokinespt_PT
dc.subjectAutoimmunitypt_PT
dc.subjectFunctional plasticitypt_PT
dc.titleMicroRNA-146a controls IFN-g production and functional plasticity of murine gd T cells by targeting Nod1pt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.citation.conferencePlaceBernapt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typeconferenceObjectpt_PT

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