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Advisor(s)
Abstract(s)
γδ T cells have emerged as key providers of the proinflammatory cytokines interleukin 17 (IL-17) and interferon-γ (IFN-γ) in various models of infection, inflammation, and autoimmunity. Our previous epigenetic and transcriptional analyses have shown that whereas CD27+ γδ T cells are committed to IFN-γ expression, the IL-17 producing CD27- subset has limited plasticity to co-express both cytokines under inflammatory conditions (Schmolka et al. Nat Immunol 2013). To further understand the molecular control of this plasticity we now investigated the potential role of microRNA (miRNA)-mediated post-transcriptional regulation.
Description
Keywords
Immunology Inflammatory cytokines Autoimmunity Functional plasticity
Citation
Schmolka N, Papotto, PH, Paula VP, Amado T, Gomes AQ, Silva-Santos B, et al. MicroRNA-146a controls IFN-g production and functional plasticity of murine gd T cells by targeting Nod1. In: 12th World Immune Regulation Meeting, Bern (Switzerland), March 14-17, 2018.