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- GrapeTree: visualization of core genomic relationships among 100,000 bacterial pathogensPublication . Zhou, Zhemin; Alikhan, Nabil-Fareed; Sergeant, Martin; Luhmann, Nina; Vaz, Cátia; Francisco, Alexandre; Carrico, Joao; Achtman, MarkCurrent methods struggle to reconstruct and visualize the genomic relationships of large numbers of bacterial genomes. GrapeTree facilitates the analyses of large numbers of allelic profiles by a static "GrapeTree Layout" algorithm that supports interactive visualizations of large trees within a web browser window. GrapeTree also implements a novel minimum spanning tree algorithm (MSTree V2) to reconstruct genetic relationships despite high levels of missing data. GrapeTree is a stand-alone package for investigating phylogenetic trees plus associated metadata and is also integrated into EnteroBase to facilitate cutting edge navigation of genomic relationships among bacterial pathogens.