Browsing by Issue Date, starting with "2024-11-05"
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- Learner-low dose aspirin preterm trial (Angola) – Low dose aspirin in pregnant women with sickle cell disease when started in the first versus second trimester: a clinical control study in AngolaPublication . Brito, Miguel; Ginete, Catarina; Gomes, Tatiana; Pitangueira, Helena; Mendes, Manuela; Furtado, Ana; Alves, Ligia; Simão, Fernanda; Gonçalves, Mauer; Morais, JoanaSickle Cell Disease (SCD) is marked by episodes of acute vaso-occlusive crises, severe anemia, acute chest syndrome, multi-organ damage and stroke, among others. Pregnancy in these patients is associated with an increased risk of adverse outcomes, such as intrauterine growth restriction, perinatal and maternal mortality, low birth weight, eclampsia, pre-eclampsia, and stroke. Therefore, increasing the surveillance during pregnancy and searching prophylactic solutions for early prevention of pregnancy complications in women with SCD in African countries, where the burden of SCD is disproportionally higher, is an urgent need. Aspirin is already widely prescribed for the prevention of cardiovascular complications, and at a low daily dose, is used during pregnancy to prevent preeclampsia, intrauterine growth restriction, and other maternal-and-fetal disorders. In pregnant women with SCD, low dose aspirin is considered safe and is recommended for those who are at severe risk of pre-eclampsia. LEARNER (ClinicalTrials.gov ID, NCT06417411), is a prospective, opened label study to evaluate the effects of daily low dose aspirin in pregnant women with SCD when initiated at the first trimester versus the second trimester of the gestational period (where it is frequently started). We hypothesize that a low dose of aspirin (100 mg/daily) initiated early in pregnancy (weeks 6-13) can be more beneficial, than when it is started in the second trimester (weeks 14-27), reducing the incidence of fetal and maternal complications. This study intends to quantify the reduction in preterm delivery, perinatal death/miscarriage, and the risk of other maternal complications including pre-eclampsia, hypertensive disorders, number of vaso-occlusive crises, need for blood transfusion, urinary tract infections, respiratory tract infections, acute chest syndrome, retained placenta, placental abruption, and vaginal bleeding, when initiating low dose aspirin in the earliest stage of the gestation period. A total of 450 pregnant women, with confirmed diagnosis of SCD, will be enrolled in this study. Enrollment is taking place at maternity and infant hospitals in Luanda, Angola. Patients who consent to participate in the study will be assigned to one of two groups based on their gestational age, confirmed through ultrasound. Participants will then start daily use of 100 mg aspirin; dosing will be suspended at time of delivery, week 36, or earlier, if deemed necessary by the clinical team. Participants will be followed from the consenting visit to 6 weeks post-partum. Recruitment started in April 2024, after regulatory approval (local EC approval nº52/CEMS/2023, and national IRB approval 99/ARMED/MINSA/2024), and to date, 15 participants have been consented and 10 are in the treatment period. The biggest challenge to date is recruiting participants in the first trimester as most pregnant women that visit the hospital, in Angola, are already at the end of the second or in the third trimester. Our strategy to increase the study's visibility and facilitate patient recruitment will be advertisements in social media and patient support groups and to reach out to local health centers around Luanda. Additionally, this study aims to build capacity in Angola for the conduction of future clinical trials, involving local research sites and hospitals, capacitating Angolan institutions and professionals in clinical trial conduction and data capture abilities, promoting national and international collaborations, and creating population awareness for clinical research studies. The study team is comprised of the scientific team, local clinical team, an electronic data capture specialty team, a site management organization (SMO), and a Contract Research Organization (CRO). This is the first of its kind in Angola, which will revolutionize research in the country and help with our understanding of many diseases by diversifying the studied population pool for SCD and all other research that will be conducted in the country following the model established by this study.
- O desenvolvimento da resistência cardiorrespiratória nas aulas de técnica de dança contemporânea em alunos do 5º ano de dança do ensino artístico especializado do Conservatório Regional Silva MarquesPublication . Abreu, Lia Vitória Nunes; Ângelo Cid NetoO presente relatório de estágio foi elaborado no âmbito do Curso de Mestrado em Ensino de Dança da Escola Superior de Dança, do Instituto Politécnico de Lisboa, no decorrer do ano letivo de 2023/2024. A proposta elaborada foi aplicada no contexto das aulas de Técnica de Dança Contemporânea do 9º ano ou 5º ano do Curso Básico de Dança do Ensino Artístico Especializado no Conservatório Regional Silva Marques. O trabalho, cujo tema foi o desenvolvimento da resistência cardiorrespiratória no contexto das aulas de Técnica de Dança Contemporânea, estruturou-se em conceitos provenientes do treino em dança e no desenvolvimento da capacidade cardiorrespiratória. Assim, foram trabalhados conceitos relacionados com princípios do treino em dança, articulados com princípios de movimento da Técnica de Flying Low no âmbito da Dança Contemporânea. Deste modo, foi possível refletir e complementar a prática pedagógica e o processo de ensino-aprendizagem no contexto do estágio. O plano de ação teve como objetivo principal a promoção e o estudo do desenvolvimento do volume máximo de oxigénio nas alunas uma vez que a dança é considerada uma atividade aeróbica. Deste modo, foram desenvolvidos exercícios de aula com diferentes intensidades e cargas, explorando o repouso ativo para gerir a fadiga das alunas, a integração da corrida em alguns exercícios, uma particularidade do treino aeróbio. O estágio foi desenvolvido com base na metodologia de pesquisa de investigação-ação, identificando e analisando os dados recolhidos a partir dos instrumentos de recolha como as grelhas de observação, questionário, diário de bordo e a aplicação de dois testes: Dance Aerobic Fitness Test e o Yo-Yo Intermittent Recovery Test. Os resultados obtidos demonstram que é possível promover, o desenvolvimento cardiorrespiratório em todas as alunas, com adaptações e estratégias metodológicas adequadas ao perfil da turma.