Browsing by Author "Santos, P."
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- Cork processing wastewater treatment/valorisation by nanofiltrationPublication . Oliveira, J.; Nunes, M.; Santos, P.; Cantinho, Paula; Minhalma, MiguelNanofiltration process for the treatment/valorisation of cork processing wastewaters was studied. A DS-5 DK 20/40 (GE Water Technologies) nanofiltration membrane/module was used, having 2.09 m(2) of surface area. Hydraulic permeability was determined with pure water and the result was 5.2 L.h(-1).m(-2).bar(-1). The membrane presents a rejection of 51% and 99% for NaCl and MgSO4 salts, respectively. Two different types of regimes were used in the wastewaters filtration process, total recycling mode and concentration mode. The first filtration regime showed that the most favourable working transmembrane pressure was 7 bar working at 25 degrees C. For the concentration mode experiments it was observed a 30% decline of the permeate fluxes when a volumetric concentration factor of 5 was reached. The permeate COD, BOD5, colour and TOC rejection values remained well above the 90% value, which allows, therefore, the concentration of organic matter (namely the tannin fraction) in the concentrate stream that can be further used by other industries. The permeate characterization showed that it cannot be directly discharged to the environment as it does not fulfil the values of the Portuguese discharge legislation. However, the permeate stream can be recycled to the process (boiling tanks) as it presents no colour and low TOC (< 60 ppm) or if wastewater discharge is envisaged we have observed that the permeate biodegradability is higher than 0.5, which renders conventional wastewater treatments feasible.
- Ecosapentanoic acid (EPA) does not affect cell kinetics in peripheral lymphocites from patients with Crohn's disease (CD) according to IL6 174G/C polymorphismPublication . Brito, Miguel; Ferreira, Paula; Guerreiro, Catarina Sousa; Malta-Vacas, Joana; Tavares, L.; Santos, P.; Pinto, A.; Cravo, MaríliaRationale: Omega 3 fatty acids have been shown to be of potential benefit in patients with CD. The aim of the present study was to evaluate whether EPA can modulate the inflammatory response according to different genotypes of IL6G174G/C polymorphism. Methods: Peripheral blood cells were collected from CD patients with different genotypes for IL6 174G/C (GG, n = 16, GC, n = 8, CC, n = 7), and lymphocytes were established in culture media. Replicates with the addition of EPA (25 mM) were analysed in a period of 24h, 48h and 72h. Expression of IL6 e a PGE2 was assessed by ELISA. Apoptosis and cellular proliferation was determined by flow cytometry.
- Estudo da leucoaraiose por transferência de magnetização e difusão em 36 doentes com status lacunarPublication . Maurício, J. Cruz; Santos, P.; Ribeiro, Margarida; Correia-Leal, A.Estuda-se por ressonância magnética (RM) da substância branca 36 idosos do Vale do Tejo com doença microvascular/leucoaraiose isquémica. A aquisição é em transferência da magnetização e difusão. Propósito de comparar duas populações com status lacunar basal, uma delas com confluência de lacunas basais (17 casos) e outra sem confluência (19 casos). Na RM desta “leucopatia vascular”, com desigual densidade lacunar, as alterações são difusas e não apenas testemunhadas pelo hiper-T2. A heterogeneidade semiológica das lesões subcorticais implica que também se estude a substância branca aparentemente normal. O coeficiente aparente de difusão será a chave do prognóstico do status lacunar avançado, quanto ao potencial risco cognitivo.