Browsing by Author "Santos, I."
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- Carcinoma da glândula de Bartholin: estudo de caso de uma metástase à distânciaPublication . Silva, I.; Santos, I.; Tavares, V.; Roque, Ruben; André, S.; Mendonça, PaulaO carcinoma adenoide quístico da glândula de Bartholin é um tumor maligno ginecológico muito raro que se manifesta como lesão sólida, móvel e dolorosa, com crescimento lento. É um tumor associado a recorrência local e metastização, que pode ocorrer vários anos depois da lesão primária. O diagnóstico clínico inclui lesão quística ou abcesso. No entanto, apresenta características morfológicas específicas, que permitem o diagnóstico citológico e histológico. O presente caso clínico refere-se a uma mulher de 48 anos diagnosticada em 2015 com carcinoma adenoide quístico da glândula de Bartholin que foi submetida a uma vulvectomia radical modificada com linfadenectomia esquerda e alargamento da margem cirúrgica. Em outubro de 2021 foram detetados dois novos nódulos vaginais, cuja biópsia confirmou tratar-se de recidiva e a avaliação citológica confirmou a metastização paratraqueal e pulmonar. Nesta apresentação de caso salientamos a pertinência da realização do Rapid On-Site Evaluation durante a colheita de amostras citológicas.
- Depressive symptomatology, temperament and oxytocin serum levels in a sample of healthy female university studentsPublication . Veiga, Luisa; Carolino, Elisabete; Santos, I.; Veríssimo, C.; Almeida, Ana; Grilo, Ana Monteiro; Brito, Miguel; Santos, Margarida Custódio dosBackground: Depressive symptomatology is prevalent among female university students with adverse effects on their quality of life and academic performance. Previous research suggested associations between depressive symptomatology and oxytocin levels and between depressive symptomatology and Temperament Traits. Despite this evidence, to the best of our knowledge, no research has studied the effects of both oxytocin serum levels and temperament dimensions on depressive symptoms in a healthy sample. The present study aimed to analyze the effect of oxytocin levels and temperament traits on depressive symptomatology in healthy female university students. Methods: All participants completed the Beck Depression Inventory and the Adult Temperament Questionnaire. Blood samples were collected between 8 and 8H30 a.m. after 12 h of fasting and between 5 and 8 days of the menstrual cycle and serum oxytocin levels were quantified using a commercial enzyme-linked immunosorbent assay. A hierarchical multiple regression model using a stepwise method was conducted to identify predictors of depression. Results: Forty-five women aged between 18 and 25 years old (19.37 ± 1.32 years) volunteered to participate in this study. Depressive symptomatology was negatively associated with oxytocin serum levels and "Negative affect" and positively associated with "Effortful control" and "Activation Control". In the final regression model, only oxytocin level was a predictor (B = - 0.090, p < 0.0001), the model explaining 65.2% of the depression variation. Oxytocin played a mediation role between "Negative effects" and Depressive symptomatology. Conclusions: Our results showed that oxytocin level, rather than personality dimensions, was associated with depressive symptomatology. These results highlight the relevance of the discussion on the use of oxytocin as a biological marker of emotional and social symptoms that characterize depression.
- Nutritional status and functional status of the pancreatic cancer patients and the impact of adjacent symptomsPublication . Santos, I.; Mendes, Lino; Mansinho, H.; Santos, Carla AdrianaRationale & aims: Pancreatic cancer (PC) is the third most common type of gastrointestinal tract cancer in Europe and the fourth leading cause of death by cancer. Its initial stage is asymptomatic Therefore, the diagnosis tends to be late leading to locally advanced stages that presuppose late and debilitating symptoms, which consequently makes the Nutritional Status (NS) get worse. The weight loss (WL), malnutrition, and oncologic cachexia, which are quite prevalent in PC patients, reflect a poor prognosis. We aimed to track and evaluate the NS and Functional Status (FS) of PC patients (hospitalized patients – HP and Day Hospital patients – DHP) and associate NS with symptoms with nutritional impact and FS. Methods: Observational cohort study in PC patients from Garcia de Orta Hospital. NS was tracked and evaluated using Nutritional Risk Screening (NRS-2002) and Patient-Generated Subjective Global Assessment (PG-SGA). To assess FS we used the Eastern Cooperative Oncology Group (ECOG), Karnofsky Performance Scale Index (KPSI), and Handgrip Dynamometer (HGD). Results: 41 PC patients (30-HP and 11-DHP). 29 patients in stage IV of the tumor. 24 with a WL >10% in the last 6 months. 37 manifest symptoms with nutritional impact. 30 to 34 malnourished according to the GLIM criteria and PG-SGA, respectively. 11 in ECOG level 2 and corresponding KPSI, 10 in level 3, and 8 in level 4. 28 patients had a value of HGD below the 10th percentile. NRS-2002, PG-SGA and GLIM criteria were positively correlated with the symptoms (p < 0.01), % WL (p < 0.01) and ECOG (p < 0.01) and negatively correlated with HGS (p < 0.05 – NRS-2002; p < 0.01 – PG-SGA and GLIM criteria). Conclusions: PC patients manifest debilitating symptoms with nutritional impact, namely severe WL and anorexia, which in turn lead to deterioration of the NS and FS. It is an oncology population with high nutritional risk and a higher prevalence of malnutrition, associated with severe % WL and symptoms and a sharp decline in FS.
- Relato de um caso: metástase à distância de carcinoma adenoide quístico da glândula de BartholinPublication . Santos, I.; Silva, I.; Tavares, V.; Roque, Ruben; André, S.; Mendonça, PaulaO carcinoma adenóide quístico (CAQ) foi descrito pela primeira vez em 1853 por Robin et al. É a segunda neoplasia maligna mais comum da glândula salivar, mas é extremamente rara na glândula de Bartholin, estando descritos 350 casos até 2018. Os carcinomas da glândula de Bartholin tendem a ser diagnosticados tardiamente, devido à sua raridade, que contrasta com alterações benignas da glândula, como quistos ou abcessos, os quais não possuem características distintas. O objetivo deste estudo é descrever os achados citomorfológicos de um caso clinico de CAQ.