Browsing by Author "Pereira, C."
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- Avaliação do efeito da associação do Rituximab ao protocolo de quimioterapia ciclofosfamida, doxorrubicina, vincristina e prednisolona (CHOP) no tratamento de linfomas Não-HodgkinPublication . Fuste, P.; Pereira, C.; Reis, A.; Serrano, V.; Caetano, Liliana Aranha; Costa, Ana MargaridaO protocolo de quimioterapia ciclofosfamida, doxorrubicina, vincristina e prednisolona (CHOP) e, posteriormente, rituximab, ciclofosfamida, doxorrubicina, vincristina e prednisolona (RCHOP) têm sido utilizados como terapêutica em Linfomas não-Hodgkin (LNH) como o Linfoma Difuso de Grandes Células B (LDGCB) e o Linfoma Folicular (LF). O LDGCB constitui o tipo de LNH mais frequente, com uma incidência de 40% e o LF representa cerca de 25% de todos os LNH-B. O anticorpo monoclonal rituximab foi associado ao protocolo de quimioterapia CHOP, pois este apresenta actividade sobre a maioria das células CD20+, sendo este um marcador expresso pela maioria das células B de linfomas. Actualmente, em oncologia, além dos ganhos clínicos que possam advir de novas opções terapêuticas, têm também vindo a ser analisadas as suas consequências a nível económico, devido ao aumento significativo das despesas com a Saúde. Assim, nos últimos anos, têm vindo a realizar-se estudos que avaliam parâmetros clínicos e de custo efectividade decorrentes da associação do rituximab ao CHOP, relativamente a este protocolo de quimioterapia isolado. Este trabalho teve como objectivo comparar os ganhos terapêuticos da associação do rituximab ao CHOP face a este protocolo de quimioterapia isolado, através da avaliação de indicadores clínicos (probabilidade de sobrevivência, probabilidade de sobrevivência sem sintomas, taxa de resposta, toxicidade, risco de infecção) e de custo efectividade descritos na literatura publicada nos últimos 5 anos.
- Evaluating the levels of endotoxins in health care facilitiesPublication . Pereira, C.; Almeida, Beatriz; Lage, B.; Marrafaia, M.; Paciência, I.; Rufo, J. Cavaleiro; Teixeira, João Paulo; Viegas, CarlaEndotoxins are biologically active lipopolysaccharides (LPSs) produced by the most external layer of cell walls of Gram-negative bacteria and are present ubiquitously in the environment. Endotoxin levels are related to the occurrence of Gram-negative bacteria and acute health effects like dry cough and shortness of breath, decrease in lung function, fever reaction and malaise, dyspnea and headaches have been described as occurring upon endotoxin exposure as well as chronic health effects caused by the inflammatory response within the airways. Although many studies have already associated endotoxin exposure, especially in workplaces, to airways disease, a threshold limit value for occupational exposure has not been set yet, and the only available reference is from the Dutch Expert Committee on Occupational Safety (DECOS) that recommends a health-based occupational exposure limit (HBROEL) for endotoxin of 90 EU /m3 over an 8-hour period. Nevertheless, this limit has been subjected to some criticism as it was established based on human volunteer exposure challenge studies and not workplace studies, and therefore, may understate the adverse effect of lowest concentrations of endotoxin. Environmental monitoring is usually performed by sampling airborne dust and subsequent analysis by the Limulus Amebocyte Lysate (LAL) assay. This study aims to assess the levels of endotoxins present in different areas of a Central Hospital in Porto, Portugal, to determine the occupational exposure risk, as well as to compare two sampling methods: sampling on glass fiber filters with air pump following the European Standard (2003) EN 14031 and sampling by vacuumed dust. Fifteen air samples and 5 dust samples were obtained.
- The role of geology in a sustainable society: perceptions of university studentsPublication . Almeida, António; Vasconcelos, Clara; Pereira, C.; Torres, Joana; Moutinho, SaraGeology has been at the service of an instrumental view of nature contributing to its exploitation, and helping providing the raw materials needed for economic development, frequently with high ecological impacts. However, Environmental Geology and Geoconservation are fields more concerned with environmental protection and its preservation. At the same time, Geology is responsible for a certain ambiguity of values, choosing the hammer as a symbol but focusing its action on the field, which helps to generate a sense of reverence for Earth. Based on these ideas, a questionnaire was applied to 36 master students who will teach Geology (20) or will exercise other professions related with it (16), in order to ascertain how respondents characterize the work of geologists related to nature, and see their opinion about the contribution of this science to a fairer and more sustainable society. The general results show that the students identify more with a less exploiting view of this science and prefer to highlight its role for a fairer and more sustainable society especially concerning a more sustainable exploitation of Earth resources and rising of awareness of geohazards. This can support the idea of paradigm changing in Geosciences, adding an element of caution to our actions instead of helping the mutilation of the planet.