Percorrer por autor "Oliveira, Margarida"
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- Frequency, characteristics and predictors oc central and peripheral neurological involvement in Sjögren’s disease: data from PORTRESS, the Portuguese registry of Sjögren’s diseasePublication . Costa, R. Pereira da; Bandeira, Matilde; Silvério-António, Manuel; Lopes, Ana Rita; Santos, Filipe Cunha; Pereira, Paulo J.; Raimundo, Diana Belchior; Cunha, Anita; Oliveira, Cláudia Pinto; Duarte, Ana Catarina; Dias, J. Madruga; Santos, Mariana Emília; Gonçalves, Maria João; Moniz, Ana Catarina; Maduro, Ana Isabel; Luis, Mariana; Valido, Ana; Oliveira, Margarida; Brites, Luísa; Tenazinha, Catarina; Khmelinskii, Nikita; Barcelos, Filipe; Fonseca, João Eurico; Romão, Vasco C.Background: Sjogren's disease (SjD) systemic affection is being increasingly recognized. The prevalence of peripheral (PNS) and central (CNS) nervous system involvement in SjD and risk factors for these manifestations have not been clearly established. Objectives: To define the clinical characteristics of SjD patients with CNS and/or PNS involvement and to find predictors of this involvement.
- Graphene oxide and its viability as a constituent in nanofertilizersPublication . Saraiva, Raquel; Ferreira, Quirina; Rodrigues, Gonçalo R.; Oliveira, MargaridaThe use of chemical fertilizers and phytochemicals is a common practice in major crop production, promoting increased production per hectare but also representing a growing environmental concern. In response to this problem, this work carried out an ecotoxicity study and characterized the changes in soil properties resulting from the use of graphene oxide (GO), a component used in the formulation of new nanofertilizer and nanobiostimulant pellets for agriculture due to its effective carrier properties and previously reported non-toxicity in other areas. Lepidium sativum L. petri dish and pot trials were performed according to the EN 16086-2 European Standard and OECD guidelines to evaluate germination, vitality, and root development. Soil parameters such as pH, electrical conductivity (EC), total organic carbon (TOC), and water holding capacity (WHC) were also monitored. Although no significant phytotoxic effects were observed at most concentrations, higher doses (2.00 mg mL−1) exhibited deviations in plant behavior and TOC levels. These findings help define the preliminary safe-use thresholds for GO in agricultural applications.
- PORTRESS – the PORTuguese Reuma.pt registry for Sjögren’S diseasePublication . Bandeira, Matilde; Silvério-António, Manuel; Costa, Roberto Pereira da; Lopes, Ana Rita; Santos, Filipe Cunha; Pereira, Paulo J.; Raimundo, Diana Belchior; Cunha, Anita; Oliveira, Cláudia Pinto; Duarte, Ana Catarina; Dias, João; Santos, Mariana Emília; Gonçalves, Maria João; Moniz, Ana Catarina; Maduro, Ana Isabel; Luís, Mariana; Valido, Ana; Oliveira, Margarida; Brites, Luísa; Tenazinha, Catarina; Vieira, Ana; Khmelinskii, Nikita; Barcelos, Filipe; Fonseca, João Eurico; Romão, Vasco C.Aims: Sjögren's disease (SjD) is a complex disease with a wide variety of manifestations and outcomes. We recently created PORTRESS, the Portuguese SjD registry within Reuma.pt. We aim to describe this registry and characterize our national cohort. Methods: We included patients with a clinical diagnosis of SjD, registered in PORTRESS up to November 2023. Demographic, clinical, treatment, and patient-reported outcomes (PROs) data were collected. Variables were compared according to parametric or non-parametric tests, as applicable. Results: A total of 1375 patients were included. Patients fulfilled AECG 2002 or ACR/EULAR 2016 classification criteria in 62% and 57% of cases, respectively, although more than half didn't have a complete assessment of all items. Of note, the vast majority (93%) had both SjD manifestations and a positive anti-Ro and/or minor salivary gland biopsy. Most patients (88%) exhibited at least one active ESSDAI domain during the course of their disease. Hydroxychloroquine and corticosteroids were used in 52% and 30% of patients, while other immunosuppressants and pilocarpine were used in 12% and 18% of cases, respectively. The mean ESSDAI at inclusion was 3.0±4.4 (range 0-42), and, at the last follow-up, 2.1±3.7 (0-31), corresponding to a significant decrease. Dryness, pain, and fatigue PROs were scored high, with a significant increase from baseline to follow-up. Conclusion: PORTRESS is a web-based SjD registry facilitating efficient nationwide data storage. It enables research, trial recruitment, and a comprehensive longitudinal view of patients' evolution. Although systemic activity improved over follow-up, symptom burden worsened when compared to baseline, underlining a major unmet need in SjD.