Browsing by Author "Marques, P."
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- 5GMEDE-5G mobile edge computing with enriched radio network information servicesPublication . Akman, A.; Monteiro, V.; Marques, P.; Rodriguez, J.; Vieira, Pedro; Marques, H.; Abdalla, A.5G has a number of challenges to solve. Higher data usage and processing power necessities have emerged from the increasing number of mobile users as well as mobile applications becoming more and more demanding. There is a significant need to reduce the latency of the mobile network while cutting down on energy consumption. Backhaul traffic needs to be optimized to avoid setting up costly backhaul connections. Many loT scenarios have conflicting requirements; the need for cheap and low complexity devices vs the need for processing power. Operators need to come up with value added services to avoid being dumb-pipe operators. The answer to these challenges and more require cloud-computing capabilities within the Radio :Access Network (RAN) as well as a platform for mobile operators and third-party application providers to utilize these computing capabilities. This is where Mobile Edge Computing (MEC), one of the key emerging technologies for 5G, comes into play. The 5GMEDE project proposes to not only develop and demonstrate a complete MEC solution, including the MEC framework, Base Station services and applications to run on top, but also offers innovative features like constraint based mobile edge selection, using data analytics to enrich and refine real-time radio network information and utilizing Software Defined Wireless Networks (SDWN) concepts to improve mobility and resource allocation services to enable operators.
- Cynara scolymus L. A promising Mediterranean extract for topical anti-aging preventionPublication . Marques, P.; Marto, J.; Gonçalves, L.M.; Pacheco, Rita; Fitas, M.; Pinto, P.; Serralheiro, M.L.M.; Ribeiro, H.Cynara scolymus L. (CS), usually known as globe artichoke, is a Mediterranean plant with antioxidant properties due to its content of polyphenols, including caffeoylquinic and dicaffeoylquinic acids. The use of bioactive ingredients or phytochemicals extracted from plant tissues in cosmetics is increasing, thus artichoke extract due to its promising constituents can be incorporated in topical formulations. The aim of this study was the chemical characterization of different CS extracts in order to investigate the antioxidant and the sun protection potential in topical formulations. Aqueous extracts were analyzed by HPLC to quantify target compounds, such as cynarin, chlorogenic acid and cynaroside. Antioxidant activity by DPPH assay and ROS scavenging activity in HaCaT cells, as well as cytotoxicity assays and sun protection factor were assessed. The results showed that CS extract and CSC fraction, one of the purified fractions, were rich in polyphenols and presented antioxidant and photoprotective activity. Then, both fractions were incorporated in two topical formulations: O/W emulsion and hydrogel. Physicochemical characterization, microbiological control, cytotoxicity assays and ROS scavenging activity in HaCaT cells were performed to ensure the quality, safety and efficacy of the products developed. In vivo studies, Human Repeat Insult Patch Testing and an assay to determine their antioxidant capacity, were also performed. Besides the excellent antioxidant and photoprotective activity, the final formulations proved to be also suitable and safe for topical use.