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Evaluating the impact of using natural fixative agents as alternatives to formaldehyde in histopathology: a systematic review
Publication . Horta, Andreia; Condesso, Nádia; Maia-Matos, Mário; Borges-Ferro, A
The histological technique involves several steps to prepare tissues for microscopic analysis, with fixation being one of the key steps. Formaldehyde is the most used fixing agent; however, it poses significant health risks and is classified as a Group 1 human carcinogen by the IARC and the NTP. This concern has prompted the search for safer alternatives. This study aims to identify a less harmful natural substitute for formaldehyde that can reduce or eliminate exposure to this hazardous reagent. To achieve this objective, a systematic review explored the potential of natural fixatives that can perform similar functions with lower toxicity.
2025-03Póster em conferência Acesso aberto Ver mais