Percorrer por autor "Creado, Joana Rita de Alexandre"
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- Characterization of the structural findings obtained through optical coherence tomography and magnetic resonance in glaucomatous optic neuropathy: systematic reviewPublication . Creado, Joana Rita de Alexandre; Camacho, Pedro; Caetano, MarcoABSTRACT - Glaucomatous optic neuropathy is structurally characterized by chronic and progressive damage to retinal ganglion cells and their axons, which form the retinal nerve fiber layer (RNFL). However, these structural alterations, which cause irreversible visual field loss, are initially asymptomatic and an earlier diagnosis becomes essential. A systematic review protocol was initially developed (ID PROSPERO = CRD42021284152) that supported the development of the systematic review (under review in Optometry and Vision Science (OVS)) to study the importance and pertinence of the potential role of magnetic resonance imaging (MRI) in the early diagnosis of glaucoma and compare with the SD-OCT structural gold standard. For this search were selected 28 studies. The results showed that several OCT and MRI findings may provide valuable insights for an earlier glaucoma diagnosis in clinical practice. It also showed that structural MRI findings appear to be mostly related to RNFL and visual field changes, while metabolic findings appear to be more closely related to ganglion cell layer (GCL) changes. These changes demonstrated a strong relationship not only with the clinical findings of the OCT but also with the severity of the pathology. This systematic review may contribute to a better understanding of which MRI parameters may play an important role in the early diagnosis of glaucoma alongside OCT due to their relationship with the stage of the pathology. So, we can conclude that MRI may be useful not only in the diagnosis but also in following up on some patients alongside OCT and the visual field.