Percorrer por autor "Chierrito, Danielly"
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- Bioactive compounds as potential angiotensin-converting enzyme II inhibitors against COVID-19: a scoping reviewPublication . Matos, Pedro Henrique de; Silva, Thalita Prates da; Mansano, Amanda Benites; Gancedo, Naiara Cássia; Tonin, Fernanda; Pelloso, Fernando Castilho; Petruco, Marcus Vinicius; Melo, Eduardo Borges de; Fernandez-Llimos, Fernando; Sanches, Andreia Cristina Conegero; Mello, João Carlos Palazzo de; Chierrito, Danielly; Araújo, Daniela Cristina de MedeirosObjective and design: The current study aimed to summarize the evidence of compounds contained in plant species with the ability to block the angiotensin-converting enzyme 2 (ACE-II), through a scoping review. Methods: PubMed and Scopus electronic databases were used for the systematic search and a manual search was performed RESULTS: Studies included were characterized as in silico. Among the 200 studies retrieved, 139 studies were listed after the exclusion of duplicates, and 74 were included for the full read. Among them, 32 studies were considered eligible for the qualitative synthesis. The most evaluated class of secondary metabolites was flavonoids with quercetin and curcumin as most actives substances and terpenes (isothymol, limonin, curcumenol, anabsinthin, and artemisinin). Other classes also evaluated were alkaloid, saponin, quinone, substances found in essential oils, and primary metabolites such as the aminoacid L-tyrosine and the lipidic compound 2-monolinolenin. Conclusion: This review suggests the most active substance from each class of metabolites, which presented the strongest affinity to the ACE-II receptor, which contributes as a basis for choosing compounds and directing further experimental and clinical investigation on the applications these compounds in biotechnological and health processes as in COVID-19 pandemic.
- Chemical constituents, anticancer and anti-proliferative potential of limonium species: a systematic reviewPublication . Gancedo, Naiara Cássia; Isolani, Raquel; Oliveira, Natalia Castelhano de; Nakamura, Celso Vataru; Araújo, Daniela Cristina Medeiros; Sanches, Andreia Cristina Conegero; Tonin, Fernanda; Fernandez-Llimos, Fernando; Chierrito, Danielly; Mello, João Carlos Palazzo deLimonium species represent a source of bioactive compounds that have been widely used in folk medicine. This study aimed to synthesize the anticancer and anti-proliferative potential of Limonium species through a systematic review. Searches were performed in the electronic databases PubMed/MEDLINE, Scopus, and Scielo and via a manual search. In vivo or in vitro studies that evaluated the anticancer or anti-proliferative effect of at least one Limonium species were included. In total, 942 studies were identified, with 33 articles read in full and 17 studies included for qualitative synthesis. Of these, 14 (82.35%) refer to in vitro assays, one (5.88%) was in vivo, and two (11.76%) were designed as in vitro and in vivo assays. Different extracts and isolated compounds from Limonium species were evaluated through cytotoxic analysis against various cancer cell lines (especially hepatocellular carcinoma—HepG2; n = 7, 41.18%). Limonium tetragonum was the most evaluated species. The possible cellular mechanism involved in the anticancer activity of some Limonium species included the inhibition of enzymatic activities and expression of matrix metalloproteinases (MMPs), which suggested anti-metastatic effects, anti-melanogenic activity, cell proliferation inhibition pathways, and antioxidant and immunomodulatory effects. The results reinforce the potential of Limonium species as a source for the discovery and development of new potential cytotoxic and anticancer agents. However, further studies and improvements in experimental designs are needed to better demonstrate the mechanism of action of all of these compounds.
- Flavonoid as possible therapeutic targets against COVID-19: a scoping review of in silico studiesPublication . Toigo, Larissa; Teodoro, Emilly Isabelli dos Santos; Guidi, Ana Carolina; Gancedo, Naiara Cássia; Petruco, Marcus Vinícius; Melo, Eduardo Borges; Tonin, Fernanda; Fernandez-Llimos, Fernando; Chierrito, Danielly; Mello, João Carlos Palazzo de; Araújo, Daniela Cristina de Medeiros; Sanches, Andréia Cristina ConegeroObjectives: This scoping review aims to present flavonoid compounds' promising effects and possible mechanisms of action on potential therapeutic targets in the SARS-CoV-2 infection process. Methods: A search of electronic databases such as PubMed and Scopus was carried out to evaluate the performance of substances from the flavonoid class at different stages of SARS-CoV-2 infection. Results: The search strategy yielded 382 articles after the exclusion of duplicates. During the screening process, 265 records were deemed as irrelevant. At the end of the full-text appraisal, 37 studies were considered eligible for data extraction and qualitative synthesis. All the studies used virtual molecular docking models to verify the affinity of compounds from the flavonoid class with crucial proteins in the replication cycle of the SARS-CoV-2 virus (Spike protein, PLpro, 3CLpro/ MPro, RdRP, and inhibition of the host's ACE II receptor). The flavonoids with more targets and lowest binding energies were: orientin, quercetin, epigallocatechin, narcissoside, silymarin, neohesperidin, delphinidin-3,5-diglucoside, and delphinidin-3-sambubioside-5-glucoside. Conclusion: These studies allow us to provide a basis for in vitro and in vivo assays to assist in developing drugs for the treatment and prevention of COVID-19.