Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.21/759
Título: Genotoxicity biomarkers micronucleus, nucleoplasmic bridges and nuclear buds
Autor: Ladeira, Carina
Palavras-chave: Anatomia patológica
Meio laboratorial
Biomarcador tumoral
Data: Set-2011
Citação: Ladeira C. Genotoxicity biomarkers micronucleus, nucleoplasmic bridges and nuclear buds. In ECNIS International Workshop of Biomarkers and Cancer, Oporto, 21st to 23rd September 2011. Poster.
Resumo: The increase of mortality from cancer brought urgency in identification and validation of predictive markers of risk and therefore early diagnosis. There is evidence that cytogenetic biomarkers are positively correlated with risk of cancer, and this is validated by studies of cohort and case-control. Cytokinesis-blocked micronucleus (CBMN) assay is used extensively in molecular epidemiology, and can be considered as a “cytome” assay covering cell proliferation, apoptosis, necrosis and chromosomal changes. The chromosomal alterations most reported and studied by the CBMN are: micronucleus (MN), nucleoplasmic bridges (NPB) and nuclear buds (NBUDS). The use of the MN assay in biomonitoring studies had a large increase in the last 15 years and international projects such as the HUMN have helped to increase the applicability and reliability of these tests.
Peer review: yes
URI: http://hdl.handle.net/10400.21/759
Aparece nas colecções:ESTeSL - Posters

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