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Heterogeneity in protocols and outcomes to study the effect of reninā€angiotensin system blockers in inflammatory bowel disease: a systematic review

2023-12Journal article Embargoed access
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dc.contributor.authorFerreiraā€Duarte, Mariana
dc.contributor.authorTonin, Fernanda
dc.contributor.authorDuarteā€AraĆŗjo, Margarida
dc.contributor.authorFernandezā€Llimos, Fernando
dc.contributor.authorMorato, Manuela
dc.date.accessioned2023-08-01T10:47:40Z
dc.date.embargo2025-08-01
dc.date.issued2023-12
dc.description.abstractBackground: The renin-angiotensin system (RAS) has been associated with inflammatory bowel disease (IBD), supporting the translational relevance of RAS blockers. Comparability of study design/outcomes is fundamental for data analysis/discussion. Objectives: We aimed at evaluating the heterogeneity among protocols and outcomes to study the effect of angiotensin-converting enzyme inhibitors or angiotensin receptor blockers in IBD. Methods: This study was performed and reported in accordance with the Cochrane recommendations and PRISMA (PROSPERO-CRD42022323853). Systematic searches were performed in PubMed, Scopus, and Web of Science. Studies that met the inclusion criteria were selected. Quality assessment of the studies was done with the SYRCLES's risk of bias tools for animal studies. Results: Thirty-five pre-clinical studies and six clinical studies were included. Chemical induction of colitis was the most used model, but variable doses of the induction agent were reported. All studies reported at least a disease activity index, a macroscopic score, or a histologic assessment, but these scores were methodologically heterogeneous and reported for different characteristics. Great heterogeneity was also found in drug interventions. Inflammatory markers assessed as outcomes were different across studies. Conclusion: Lack of standardization of protocols and outcomes among studies threatens the evidence on how RAS blockers influence IBD outcomes.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationFerreira-Duarte M, Tonin FS, Duarte-AraĆŗjo M, Fernandez-Llimos F, Morato M. Heterogeneity in protocols and outcomes to study the effect of renin-angiotensin system blockers in inflammatory bowel disease: a systematic review. Fundam Clin Pharmacol. 2023;37(6):1139-52.pt_PT
dc.identifier.doi10.1111/fcp.12935pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/16352
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherWileypt_PT
dc.relation.publisherversionhttps://onlinelibrary.wiley.com/doi/10.1111/fcp.12935pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectAngiotensin-converting enzymept_PT
dc.subjectColitispt_PT
dc.subjectHeterogeneitypt_PT
dc.subjectInflammatory bowel diseasept_PT
dc.subjectRenin-angiotensin system blockerspt_PT
dc.subjectVariabilitypt_PT
dc.titleHeterogeneity in protocols and outcomes to study the effect of reninā€angiotensin system blockers in inflammatory bowel disease: a systematic reviewpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage1152pt_PT
oaire.citation.issue6pt_PT
oaire.citation.startPage1139pt_PT
oaire.citation.titleFundamental & Clinical Pharmacologypt_PT
oaire.citation.volume37pt_PT
person.familyNameTonin
person.givenNameFernanda
person.identifier.ciencia-idD01C-C700-9411
person.identifier.orcid0000-0003-4262-8608
person.identifier.ridO-2050-2017
person.identifier.scopus-author-id56085115800
rcaap.rightsembargoedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication61ded30e-ecec-4b3e-b953-2293e080ebdd
relation.isAuthorOfPublication.latestForDiscovery61ded30e-ecec-4b3e-b953-2293e080ebdd

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