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Orientador(es)
Resumo(s)
Delirium presents a significant clinical challenge, primarily due to its profound impact on patient outcomes and the limitations of the current diagnostic methods, which are largely subjective. During the COVID-19 pandemic, this challenge was intensified as the frequency of delirium assessments decreased in Intensive Care Units (ICUs), even as the prevalence of delirium among critically ill patients increased. The present study evaluated how the serum molecular fingerprint, as acquired by Fourier-Transform InfraRed (FTIR) spectroscopy, can enable the development of predictive models for delirium. A preliminary univariate analysis of serum FTIR spectra indicated significantly different bands between 26 ICU patients with delirium and 26 patients without, all
of whom were admitted with COVID-19. However, these bands resulted in a poorly performing
Naïve-Bayes predictive model. Considering the use of a Fast-Correlation-Based Filter for feature selection, it was possible to define a new set of spectral bands with a wider coverage of molecular functional groups. These bands ensured an excellent Naïve-Bayes predictive model, with an AUC, a sensitivity, and a specificity all exceeding 0.92. These spectral bands, acquired through a minimally invasive analysis and obtained rapidly, economically, and in a high-throughput mode, therefore offer significant potential for managing delirium in critically ill patients.
Descrição
Palavras-chave
delirium biomarkers FTIR spectroscopy serum omics
Contexto Educativo
Citação
Viegas Ana, Araújo Rúben, Ramalhete Luís, Von Rekowski Cristiana, Fonseca Tiago AH, Bento Luís, Calado Cecília RC – Discovery of delirium biomarkers through minimally invasive serum molecular fingerprinting. Metabolites 2024, 14(6), 301; https://doi.org/10.3390/metabo14060301
Editora
MDPI