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Effects of the ketogenic diet in the treatment of gliomas: a systematic review

2022-02Journal article Open access
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dc.contributor.authorSargaço, Beatriz
dc.contributor.authorOliveira, Patrícia
dc.contributor.authorAntunes, Maria Da Luz
dc.contributor.authorMoreira, Ana Catarina
dc.date.accessioned2022-02-28T12:33:30Z
dc.date.available2022-02-28T12:33:30Z
dc.date.issued2022-02
dc.descriptionFCT_UIDB/05608/2020. FCT_UIDP/05608/2020.pt_PT
dc.description.abstractThe ketogenic diet (KD) is a restrictive therapeutic diet, distinguished by being hyperlipidic, normoproteic, and hypoglucidic. This diet stimulates biochemical changes related to fasting periods to achieve systemic ketosis. The metabolic particularities of glioma tumors motivated the rise in investigations and nutritional strategies, such as KD, to modulate the glycemic response as a treatment. This systematic review followed the PRISMA recommendations and was published in PROSPERO, with the identification CRD42021264173. The databases used were EMBASE, PubMed/Medline, Scopus, and Web of Science, and the studies were analyzed using the web-based application Rayyan. To analyze the risk of bias, Cochrane RevMan 5 software was used. For the analysis and treatment of statistical data, Microsoft® Excel® was used. A total of nine original articles were included. Data on survival, symptomology, and quality of life were collected. Mean overall survival was 15.9 months. Constipation and fatigue were the most reported symptoms. In 44.4% of the studies, an improvement in the quality of life was found. The KD is supported by most published studies as an effective therapy in the treatment of malignant gliomas due to its positive effects on patient survival. It was not possible to conclude the effectiveness of KD on quality of life.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSargaço B, Oliveira PA, Antunes ML, Moreira AC. Effects of the ketogenic diet in the treatment of gliomas: a systematic review. Nutrients. 2022;14(5):1007.pt_PT
dc.identifier.doi10.3390/nu14051007pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/14346
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationFCT_UIDB/05608/2020pt_PT
dc.relationFCT_UIDP/05608/2020pt_PT
dc.relation.publisherversionhttps://www.mdpi.com/2072-6643/14/5/1007/htmpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectNutritionpt_PT
dc.subjectDieteticspt_PT
dc.subjectKetogenic dietpt_PT
dc.subjectGliomapt_PT
dc.subjectGlioblastomapt_PT
dc.subjectSurvivalpt_PT
dc.subjectFCT_UIDB/05608/2020pt_PT
dc.subjectFCT_UIDP/05608/2020pt_PT
dc.titleEffects of the ketogenic diet in the treatment of gliomas: a systematic reviewpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue5pt_PT
oaire.citation.startPage1007pt_PT
oaire.citation.titleNutrientspt_PT
oaire.citation.volume14pt_PT
person.familyNameSargaço
person.familyNameAlmeida Oliveira
person.familyNameAntunes
person.familyNameMoreira
person.givenNameBeatriz
person.givenNamePatrícia
person.givenNameMaria Luz
person.givenNameAna Catarina
person.identifier2087122
person.identifier.ciencia-id421B-C686-77E0
person.identifier.ciencia-idB111-6F38-5904
person.identifier.ciencia-idC81E-CC41-DFB0
person.identifier.orcid0000-0003-1551-9529
person.identifier.orcid0000-0003-2844-8934
person.identifier.orcid0000-0003-0942-7601
person.identifier.orcid0000-0001-7031-6738
person.identifier.ridB-8661-2015
person.identifier.scopus-author-id57202291460
person.identifier.scopus-author-id16234261500
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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relation.isAuthorOfPublication1ffb19f2-5505-4dd2-81a2-6992a372d11b
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relation.isAuthorOfPublication.latestForDiscovery62c8f60a-96fa-4d43-af1b-b7e066c23d6c

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