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Outer retina and choroidal thickness in intermediate age-related macular degeneration: reticular pseudodrusen findings

2018-05Journal article Restricted access
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dc.contributor.authorCamacho, Pedro
dc.contributor.authorDutra-Medeiros, Marco
dc.contributor.authorCabral, Diogo
dc.contributor.authorSilva, Rufino
dc.date.accessioned2018-09-21T10:35:30Z
dc.date.available2018-09-21T10:35:30Z
dc.date.issued2018-05
dc.description.abstractPurpose: To evaluate outer retina and choroidal thickness in subjects with intermediate age-related macular degeneration (iAMD) and to describe associations with the presence of reticular pseudodrusen (RPD). Methods: This was a retrospective, cross-sectional analysis of 157 consecutive eyes (specifically: 62 eyes classified as having RPD and 95 eyes with drusen ≥125 μm). Only cases with digital color fundus photographs, red-free, and infrared, obtained and graded according to the Age-Related Eye Disease Study to define iAMD, were used for this study. Outer retina and choroidal thickness were manually segmented and quantified at 12 locations in the horizontal meridian. Results: RPD appeared to be associated with thinning of the outer layers even after adjustment for gender and age. The presence of RPD in iAMD decreased with increase of choroidal thickness (total odds ratio [OR] 0.991, 95% confidence interval [CI] 0.985-0.996; nasal OR 0.992, 95% CI 0.986-0.997), with increased thickness of the myoid zone of the photoreceptors (total OR 0.812, 95% CI 0.688-0.958; nasal OR 0.863, 95% CI 0.755-0.987) and with increased thickness of the outer segment of the photoreceptors (total OR 0.850, 95% CI 0.731-0.989; nasal OR 0.857, 95% CI 0.736-0.989). Conclusions: The greatest differences between eyes with and without RPD are found at the level of the choroidal thickness and at the level of the photoreceptors.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationCamacho P, Dutra-Medeiros M, Cabral D, Silva R. Outer retina and choroidal thickness in intermediate age-related macular degeneration: reticular pseudodrusen findings. Ophthalmic Res. 2018;59(4):212-20.pt_PT
dc.identifier.doi10.1159/000484349pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/8875
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherKarger Publisherspt_PT
dc.relation.publisherversionhttps://www.karger.com/Article/Abstract/484349pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectAgedpt_PT
dc.subjectAged, 80 and overpt_PT
dc.subjectChoroidpt_PT
dc.subjectCross-Sectional Studiespt_PT
dc.subjectFemalept_PT
dc.subjectHumanspt_PT
dc.subjectMacular Degenerationpt_PT
dc.subjectMalept_PT
dc.subjectMiddle Agedpt_PT
dc.subjectPhotoreceptor Cells, Vertebratept_PT
dc.subjectRetinal Drusenpt_PT
dc.subjectRetrospective Studiespt_PT
dc.subjectOptical coherence tomographypt_PT
dc.subjectElderlypt_PT
dc.subjectRetinal thicknesspt_PT
dc.titleOuter retina and choroidal thickness in intermediate age-related macular degeneration: reticular pseudodrusen findingspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage220pt_PT
oaire.citation.issue4pt_PT
oaire.citation.startPage212pt_PT
oaire.citation.titleOphthalmic Researchpt_PT
oaire.citation.volume59pt_PT
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT

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