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A cohort study of forced vital capacity, airway obstruction, and survival in the multinational Burden of Obstructive Lung Disease study

2026-04Artigo científico Acesso aberto
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datacite.subject.sdg03:Saúde de Qualidade
dc.contributor.authorBurney, Peter G. J.
dc.contributor.authorBagkeris, Emmanouil
dc.contributor.authorPotts, James
dc.contributor.authorNielsen, Rune
dc.contributor.authorDevereux, Graham
dc.contributor.authorEl Rhazi, Karima
dc.contributor.authorAquart-Stewart, Althea
dc.contributor.authorNafees, Asaad A.
dc.contributor.authorKoul, Parvaiz
dc.contributor.authorMahesh, Padukudru Anand
dc.contributor.authorAgarwal, Dhiraj
dc.contributor.authorJuvekar, Sanjay
dc.contributor.authorGislason, Thorarinn
dc.contributor.authorDias, Maria Hermínia Monteiro Brites
dc.date.accessioned2026-08-28T12:21:24Z
dc.date.available2026-08-28T12:21:24Z
dc.date.issued2026-04
dc.descriptionThe baseline study was supported by several funders, including the Wellcome Trust (085790/Z/08/Z). The follow-up study was funded by the UK Medical Research Council (MR/R011192/1) and AstraZeneca AB (ESR-17-13417).
dc.description.abstractBackground: In the USA, higher forced vital capacity (FVC) is linked with longer survival, and FVC is associated with survival independently of ethnicity. The implications for the low FVC values in parts of Asia and Africa are unknown. Methods: We used data from 16 sites of the multinational Burden of Obstructive Lung Disease (BOLD) study that completed follow-up of participants between 2019 and 2021 and reported at least five deaths between baseline and follow-up. We assessed the association of mortality with FVC and Forced Expiratory Volume in 1 second (FEV1)/FVC ratio within each site using Cox proportional hazards models. These models were adjusted for age, smoking, height, and weight. Effect estimates from all sites were combined using meta-analysis. Systematic regional differences were investigated. Results: Of 9927 study participants with follow-up data, 1120 (11.3%) had died [mean follow-up = 8.7 years, standard deviation (SD) = 3.3 years]. Baseline post-bronchodilator FVC and FEV1/FVC were inversely associated with mortality. When both FVC and FEV1/FVC were mutually adjusted for each other, the decreased mortality rates were more pronounced for each SD higher FVC at baseline [44% (95% confidence interval (CI): 25%, 58%) for men and 28% (95% CI: 11%, 41%) for women] than for FEV1/FVC at baseline [14% (95% CI: 8%, 20%) for men and 7% (95% CI: -10%, 21%) for women]. The probability of true regional differences was low. Conclusions: People with a higher FVC adjusted for age, sex, and height have a longer survival. Regional adjustments to lung function standards are inappropriate when assessing prognosis.eng
dc.identifier.citationBurney PG, Bagkeris E, Potts J, Nielsen R, Devereux G, BOLD Collaborative Research Group [Dias HB], et al. A cohort study of forced vital capacity, airway obstruction, and survival in the multinational Burden of Obstructive Lung Disease study. Int J Epidemiol. 2026;55(3):dyag093.
dc.identifier.doi10.1093/ije/dyag093
dc.identifier.issn0300-5771
dc.identifier.issn1464-3685
dc.identifier.urihttp://hdl.handle.net/10400.21/23029
dc.language.isoeng
dc.peerreviewedyes
dc.publisherOxford University Press (OUP)
dc.relation.hasversionhttps://academic.oup.com/ije/article/55/3/dyag093/8703427
dc.relation.ispartofInternational Journal of Epidemiology
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectPneumology
dc.subjectLung function
dc.subjectAirflow obstruction
dc.subjectSurvival analysis
dc.subjectVital capacity
dc.titleA cohort study of forced vital capacity, airway obstruction, and survival in the multinational Burden of Obstructive Lung Disease studyeng
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue3
oaire.citation.startPagedyag093
oaire.citation.titleInternational Journal of Epidemiology
oaire.citation.volume55
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameDias
person.givenNameMaria Hermínia Monteiro Brites
person.identifier.orcid0000-0003-1257-8734
relation.isAuthorOfPublication4ba812bb-8b70-4413-af7a-91e0f04cbad7
relation.isAuthorOfPublication.latestForDiscovery4ba812bb-8b70-4413-af7a-91e0f04cbad7

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